Open celled foams, implants including them and processes for making same

• US 8,487,012 B2
• Filed: 01/25/2011
• Issued: 07/16/2013
• Est. Priority Date: 01/28/2010
• Status: Active Grant

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Goraltchouk, Alexei, Thompson, Jordan M., Van Epps, Dennis E.
• Primary Examiner(s): Gulakowski, Randy
• Assistant Examiner(s): WALES, CHRISTINA H
• Application Number:
  US13/012,991
• Publication Number:
  US 20110184531A1
• Time in Patent Office: 903 Days
• Field of Search: 521/65, 121/898
• US Class Current: 521/62
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: B32B 5/16 characterised by features of a layer formed of particles, e.g. chips, powder or granules layer formed of natural mineral particles B32B19/00; layer being formed of wood fibres, chips or particles B32B21/02
• CPC Class Codes: B32B 5/18 characterised by features of a layer of foamed material
• CPC Class Codes: C08J 2201/046 Elimination of a polymeric phase
• CPC Class Codes: C08J 2201/0502 the liquid phase being organic
• CPC Class Codes: C08J 2205/05 Open cells, i.e. more than 50% of the pores are open
• CPC Class Codes: C08J 2207/10 Medical applications, e.g. biocompatible scaffolds
• CPC Class Codes: C08J 2383/04 Polysiloxanes
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• CPC Class Codes: C08J 9/28 by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/249921 Web or sheet containing structurally defined element or component
• CPC Class Codes: Y10T 428/268 Monolayer with structurally defined element

Abstract

Described herein are open celled foams including a matrix of interconnected spheres. Also described herein are methods of making open celled foams as well as making composite members with open celled foam coatings covering at least a portion of the composite member. The open celled foams described herein are silicone based materials and can be used to coat implants such as breast implants and function to encourage tissue ingrowth and reduce capsular formation.

Claims

1. A soft tissue implant comprising:

a textured coating on at least a portion of said implant, said coating comprising a matrix of interconnected spheres having a physical void space of about 50% to about 70%, said spheres comprising substantially pure silicone.

2. The soft tissue implant of claim 1 wherein said matrix of interconnected spheres has a theoretical void space of about 50% to about 99%.

3. The soft tissue implant of claim 2 wherein said theoretical void space is between about 60% and about 88%.

4. The soft tissue implant of claim 1 wherein said spheres have a diameter of between about 25 μ

m and about 200 μ

m.

5. A soft tissue implant comprising:

a textured coating on at least a portion of said implant, said coating comprising a matrix of interconnected spheres having a theoretical void space of between about 60% and about 88%, said spheres comprising substantially pure silicone.

6. A breast implant comprising:

a fillable elastomeric shell; and

a textured coating on at least a portion of said shell, said coating comprising a matrix of interconnected spheres having a having a physical void space of about 50% to about 70%, said spheres comprising substantially pure silicone.

7. The soft tissue implant of claim 6 wherein said spheres have a diameter of between about 25 μ

m and about 200 μ

m.

8. A breast implant comprising:

a fillable elastomeric shell; and

a textured coating on at least a portion of said shell, said coating comprising a matrix of interconnected spheres having a theoretical void space of between about 60% and about 88%, said spheres comprising substantially pure silicone.

9. The soft tissue implant of claim 8 wherein said spheres have a diameter of between about 25 μ

m and about 200 μ

m.