X-ray method and apparatus used in conjunction with a charged particle cancer therapy system

• US 8,487,278 B2
• Filed: 05/21/2009
• Issued: 07/16/2013
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Vladimir Yegorovich Balakin
• Original Assignee: Vladimir Yegorovich Balakin
• Inventors: Balakin, Vladimir Yegorovich
• Primary Examiner(s): Vanore, David A
• Assistant Examiner(s): STOFFA, WYATT A
• Application Number:
  US12/994,129
• Publication Number:
  US 20110150180A1
• Time in Patent Office: 1,517 Days
• Field of Search: 250/492.1, 250/492.3, 378/65
• US Class Current: 250/492.1
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: G21K 1/087 by electrical means
• CPC Class Codes: G21K 1/093 by magnetic means
• CPC Class Codes: G21K 1/14 using charge exchange devices, e.g. for neutralising or changing the sign of the electrical charges of beams producing or accelerating neutral particle beams H05H3/00
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/04 Magnet systems , e.g. undulators, wigglers free-electron laser H01S3/0903; Energisation thereof
• CPC Class Codes: H05H 7/08 Arrangements for injecting particles into orbits
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention comprises an X-ray method and apparatus used in conjunction with charged particle radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system, has an elongated lifetime, and/or that is synchronized with patient respiration. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor, which are usable for: fine tuning body alignment relative to the proton beam path and/or to control the proton beam path to accurately and precisely target the tumor.

Claims

1. An X-ray apparatus as part of a particle beam cancer therapy system, said particle beam cancer therapy system irradiating a tumor of a patient with a charged particle beam during use, said apparatus comprising:

an X-ray generation source located within forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;

(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam;

an electron generating cathode having a first cross-sectional distance, wherein X-rays are generated by electrons from said cathode striking said tungsten anode;

a control electrode;

a plurality of accelerating electrodes;

a magnetic lens; and

a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and said anode, said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet combining to form a substantially parallel electron beam with an electron beam cross-sectional area,

wherein a cross-sectional area of said cathode is greater than eight times that of the electron beam cross-sectional area,

wherein said X-ray generation source comprises a tungsten anode, wherein said substantially parallel electron beam comprises an oblong cross-sectional shape, wherein geometry of said X-ray generation source yields an X-ray beam comprising a nearly circular cross sectional shape when struck by the electron beam having said oblong cross-sectional shape, the X-ray beam running substantially in parallel with the charged particle beam, and

wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam.

2. The apparatus of claim 1, further comprising:

a focusing control electrode; and

accelerating electrodes, said control electrode and said accelerating electrodes located between said cathode and said anode, said focusing control electrode focusing electrons from said first cross-sectional distance to a second cross-sectional distance, wherein said second cross-sectional distance is less than one-half of said first cross-sectional distance.

3. The apparatus of claim 1, further comprising a cooling element connected to a backside of said tungsten anode.

4. The apparatus of claim 1, wherein use of said X-ray generation source occurs within thirty seconds of subsequent use of the charged particle beam for tumor therapy.

5. The apparatus of claim 4, further comprising an X-ray tomography system, comprising:

a rotatable platform holding the patient,

wherein said rotatable platform rotates through about three hundred sixty degrees during an irradiation period of the patient,

wherein X-rays from said X-ray generation source yield images from greater than four rotation positions of said rotatable platform.

6. The apparatus of claim 1, wherein multi-field images of the tumor are collected by rotating a patient holding platform between collection of X-ray images, wherein the X-ray images occur in at least ten rotation positions of said platform, wherein the X-ray images are created using X-rays from said X-ray generation source.

7. The apparatus of claim 1, further comprising:

a respiration sensor generating a respiration signal, said respiration signal corresponding to a breathing cycle of the patient;

a rotatable platform holding the patient,

wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient,

wherein said X-ray generation source is timed using said respiration signal to produce X-ray images at a set point in the breathing cycle,

wherein said X-ray images represent greater than ten rotation positions of said rotatable platform, and

wherein the X-ray images combine to form a 3-dimensional image of the tumor.

8. The apparatus of claim 1, further comprising:

a synchrotron accelerating the charged particle beam;

a respiration sensor generating a respiration signal, said respiration signal corresponding to a respiration cycle of the patient;

a rotatable platform holding the patient,

wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient,

wherein said synchrotron uses said respiration signal to deliver said charged particle beam to the tumor at a set point in said respiration cycle,

wherein said delivery of said charged particle beam at said set point of the respiration cycle occurs in greater than four rotation positions of said rotatable platform, and

wherein the tumor is targeted using X-ray images collected using X-rays from said X-ray generation source.

9. The apparatus of claim 8, wherein said apparatus yields the X-ray images at said set point of the respiration cycle.

10. The apparatus of claim 8, wherein said respiration sensor comprises a force meter strapped to the patient'"'"'s chest.

11. The apparatus of claim 8, wherein said respiration sensor comprises:

a first thermal resistor positioned proximate the patient'"'"'s nose;

a second thermal resistor positioned both out of an exhalation path of the patient and in the same local room environment as said rotatable platform and the patient,

wherein said respiration signal is generated using differences between readings from said first thermal resistor and said second thermal resistor.

12. The apparatus of claim 8, further comprising:

a display screen displaying breath control commands to the patient.

13. The apparatus of claim 8, wherein said respiration signal is used in generating a breath control command and wherein said breath control command comprises a countdown to when the patient'"'"'s breath is to be held.

14. The apparatus of claim 8, wherein said delivery of the charged particle beam at said set point of said respiration cycle occurs in greater than twenty rotation positions of said rotatable platform, wherein ingress energy of said charged particle beam is circumferentially distributed about the tumor.

15. The apparatus of claim 1, further comprising a synchrotron, wherein said synchrotron comprises:

a radio-frequency cavity system comprising a first pair of blades for inducing betatron oscillation;

a foil yielding slowed charged particles from particles in the charged particle beam having sufficient betatron oscillation to traverse said foil, wherein the slowed charged particles pass through a second pair of blades having an extraction voltage directing the charged particles out of said synchrotron through a Lambertson extraction magnet.

16. The apparatus of claim 15, wherein said radio-frequency cavity system for inducing betatron oscillation is timed using said respiration signal.

17. The apparatus of claim 15, wherein said synchrotron comprises:

exactly four turning sections; and

no quadrupoles in the circulating path of the synchrotron.

18. The apparatus of claim 15, wherein said synchrotron comprises:

exactly four, ninety degree, turning sections.

19. The apparatus of claim 18, wherein each of said four, ninety degree, turning sections comprises four magnets, wherein each of said four turning magnets comprise two beveled focusing edges.

20. The apparatus of claim 1, further comprising an injection system, said injection system comprising a magnetic material at least partially contained in a plasma chamber, said plasma chamber yielding a negative ion beam converted at a converting foil into the charged particle beam.

21. An X-ray method as part of a particle beam cancer therapy system, said particle beam cancer therapy system irradiating a tumor of a patient with a charged particle beam during use, said method comprising the steps of:

generating X-rays with an X-ray generation source located within forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;

(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam;

providing a synchrotron, wherein said synchrotron comprises;

a radio-frequency cavity system comprising a first pair of blades for inducing betatron oscillation; and

a foil yielding slowed charged particles from particles in the charged particle beam having sufficient betatron oscillation to traverse said foil;

directing the charged particles out of said synchrotron through a Lambertson extraction magnet after the slowed charged particles pass through a second pair of blades having an extraction voltage; and

timing said radio-frequency cavity system for inducing betatron oscillation to said respiration signal,

wherein the X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam.

22. The method of claim 21, wherein said X-ray generation source comprises a tungsten anode.

23. The method of claim 22, further comprising the step of:

generating electrons with a cathode, said cathode having a first cross-sectional distance, wherein the X-rays are generated by the electrons from said cathode striking said tungsten anode.

24. The method of claim 23, further comprising the steps of:

focusing the electrons from said first cross-sectional distance to a second cross-sectional distance with a focusing control electrode; and

accelerating the electrons with accelerating electrodes, said focusing control electrode and said accelerating electrodes located between said cathode and said anode.

25. The method of claim 23, further comprising the step of:

forming a substantially parallel electron beam with a control electrode, accelerating electrodes, a magnetic lens, and a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and said anode,

wherein the electron beam comprises a cross-sectional area, wherein a cross-sectional area of said cathode is greater than about eight times that of the electron beam cross-sectional area.

26. The method of claim 25, further comprising the step of:

forming a substantially circular cross-section X-ray beam, wherein said substantially parallel electron beam comprises an oblong cross-sectional shape, wherein geometry of said X-ray generation source yields the substantially circular cross section X-ray when struck by the electron beam having said oblong cross-sectional shape, the X-ray beam running substantially in parallel with the charged particle beam.

27. The method of claim 25, further comprising the step of:

cooling said tungsten anode with a cooling element connected to a backside of said tungsten anode.

28. The method of claim 21, further comprising the step of:

using said X-ray generation source within thirty seconds of subsequent use of the charged particle beam for tumor therapy.

29. The method of claim 28, further comprising the steps of:

holding the patient with a rotatable platform;

rotating said rotatable platform through about three hundred sixty degrees during an irradiation period of the patient;

producing images, wherein X-rays from said X-ray generation source yield the images from greater than four rotation positions of said rotatable platform; and

combining said images to form a three-dimensional image of the tumor.

30. The method of claim 21, further comprising the step of:

producing multi-field images of the tumor, wherein the multi-field images are collected by rotating a patient holding platform between collection of X-ray images,

wherein the X-ray images occur in at least ten rotation positions of said platform,

wherein the X-ray images are created using X-rays from said X-ray generation source.

31. The method of claim 21, further comprising the steps of:

generating a respiration signal with a respiration sensor, said respiration signal corresponding to a breathing cycle of the patient;

rotating a rotatable platform, said rotatable platform holding the patient, wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient;

timing said X-ray generation source using said respiration signal to produce X-ray images at a set point in the breathing cycle, wherein said X-ray images represent greater than ten rotation positions of said rotatable platform; and

combining the X-ray images to form a three-dimensional image of the tumor.

32. The method of claim 21, further comprising the steps of:

accelerating the charged particle beam with a synchrotron;

generating a respiration signal using a respiration sensor, said respiration signal corresponding to a respiration cycle of the patient;

rotating the patient with a rotatable platform, wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient;

delivering the charged particle beam to the tumor at a set point in the respiration cycle using the respiration signal,

wherein said delivery of said charged particle beam at said set point of the respiration cycle occurs in greater than four rotation positions of said rotatable platform, and

wherein the tumor is targeted using X-ray images collected using X-rays from said X-ray generation source.

33. The method of claim 32, further comprising the step of:

generating the X-ray images at said set point of the respiration cycle.

34. The method of claim 32, wherein said respiration sensor comprises a force meter strapped to the patient'"'"'s chest.

35. The method of claim 32, further comprising the steps of:

positioning a first thermal resistor proximate the patient'"'"'s nose;

positioning a second thermal resistor both out of an exhalation path of the patient and in the same local room environment as said rotatable platform and the patient; and

generating said respiration signal using differences between readings from said first thermal resistor and said second thermal resistor.

36. The method of claim 32, further comprising the step of:

displaying breath control commands to the patient on a display screen.

37. The method of claim 32, further comprising the step of:

generating a breath control command using said respiration signal, wherein said breath control command comprises a countdown to when the patient'"'"'s breath is to be held.

38. The method of claim 32, further comprising the step of:

circumferentially distributing ingress energy of said charged particle beam about the tumor by delivering the charged particle beam at said set point of said respiration in greater than twenty rotation positions of said rotatable platform.

39. The method of claim 21, wherein said synchrotron comprises:

exactly four turning sections; and

no quadrupoles in the circulating path of the synchrotron.

40. The method of claim 21, wherein said synchrotron comprises:

exactly four, ninety degree, turning sections.

41. The method of claim 40, wherein each of said four, ninety degree, turning sections comprises four magnets, wherein each of said four turning magnets comprise two beveled focusing edges.

42. The method of claim 21, further comprising the step of:

converting a negative ion beam at a converting foil into the charged particle beam, wherein an injection system comprising a magnetic material at least partially contained in a plasma chamber yields the negative ion beam.