Self-calibrating rate-adaptive pacemaker

• US 8,494,632 B2
• Filed: 09/12/2011
• Issued: 07/23/2013
• Est. Priority Date: 09/08/2000
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Sun, Weimin, Jones, Bruce R., Lang, Douglas J., Hopper, Donald L.
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US13/230,563
• Publication Number:
  US 20120004696A1
• Time in Patent Office: 680 Days
• Field of Search: None
• US Class Current: 607/19
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

Claims

1. A rate-adaptive pacemaker, comprising:

a sensor configured to sense exertion levels; and

a microprocessor coupled to the sensor, the microprocessor configured to;

collect maximum exertion levels during a specified first period;

update a maximum exercise capacity using the maximum exertion levels collected during the specified first period; and

adjust a response factor such that the updated maximum exercise capacity is mapped to a specified maximum sensor indicated rate, the response factor being a slope of a rate response curve mapping exertion levels to sensor indicated rates.

2. The pacemaker of claim 1, wherein the microprocessor is configured to:

collect the maximum exertion levels for specified second periods during the specified first period; and

set the maximum exercise capacity to a maximum of the maximum exertion levels collected for the specified second periods during the specified first period.

3. The pacemaker of claim 1, wherein the sensor comprises a minute ventilation sensor.

4. The pacemaker of claim 1, wherein the sensor comprises an accelerometer.

5. The pacemaker of claim 1, wherein the rate response curve is a dual-slope curve, and the response factor changes from a low rate response factor to a high rate response factor at a heart rate breakpoint a percentage of a difference between maximum and minimum sensor indicated rates defined by the rate response curve, and the microprocessor is configured to adjust the response factor with the heart rate breakpoint maintained at a fixed percentage of the difference between the maximum and minimum sensor indicated rates.

6. The pacemaker of claim 1, wherein the rate response curve is a dual-slope curve, and the response factor changes from a low rate response factor to a high rate response factor at a heart rate breakpoint being a percentage of a difference between maximum and minimum sensor indicated rates defined by the rate response curve, and the microprocessor is configured to adjust the response factor with the heart rate breakpoint maintained at a dynamic percentage of the difference between maximum and minimum sensor indicated rates that changes with the maximum exercise capacity.

7. The pacemaker of claim 1, wherein the microprocessor is further configured to:

collect maximum sensor indicated rates during the specified first period;

compute an average maximum exertion level using the maximum exertion levels collected during the specified first period;

compute an average maximum sensor indicated rate using the maximum sensor indicated rates collected during the specified first period;

compute a sensor target rate as a function of the average maximum exertion level and the maximum exercise capacity; and

adjust the slope of the rate response curve using the average maximum sensor indicated rate and the sensor target rate.

8. The pacemaker of claim 7, wherein the microprocessor is configured to:

collect the maximum exertion levels for specified second periods during the specified first period;

set the maximum exercise capacity to a maximum of the maximum exertion levels collected for the specified second periods during the specified first period;

collect the maximum exertion levels and the maximum sensor indicated rates for specified second periods during the specified first period; and

compute the average maximum exertion level being an average of the maximum exertion levels collected for the specified second periods during the specified first period and the average maximum sensor indicated rate being an average of the maximum sensor indicated rates collected for the specified second periods during the specified first period.

9. The pacemaker of claim 8, wherein the microprocessor is configured to adjust the slope of the rate response curve periodically using a difference between the average maximum sensor indicated rate and the sensor target rate.

10. The pacemaker of claim 8, wherein the microprocessor is configured to compute moving average values of the sensed exertion levels and moving average values of the sensor indicated rates.

11. A rate-adaptive pacemaker, comprising:

a sensor configured to sense exertion levels; and

a microprocessor coupled to the sensor, the microprocessor configured to;

collect maximum exertion levels and maximum sensor indicated rates during a specified first period;

compute an average maximum exertion level using the maximum exertion levels collected during the specified first period;

compute an average maximum sensor indicated rate using the maximum sensor indicated rates collected during the specified first period;

compute a sensor target rate as a function of the average maximum exertion level and a maximum exercise capacity; and

adjust a response factor using the average maximum sensor indicated rate and the sensor target rate, the response factor being a slope of a rate response curve that maps exertion levels to sensor indicated rates.

12. The pacemaker of claim 11, wherein the microprocessor is configured to:

collect the maximum exertion levels and maximum sensor indicated rates for specified second periods during the specified first period; and

compute the average maximum exertion level being an average of the maximum exertion levels collected for the specified second periods during the specified first period and the average maximum sensor indicated rate being an average of the maximum sensor indicated rates collected for the specified second periods during the specified first period.

13. The pacemaker of claim 12, wherein the microprocessor is configured to compute moving average values of the sensed exertion levels and moving average values of the sensor indicated rates.

14. The pacemaker of claim 11, wherein the microprocessor is configured to adjust the response factor periodically using a difference between the average maximum sensor indicated rate and the sensor target rate.

15. The pacemaker of claim 14, wherein the microprocessor is configured to adjust the response factor in specified increments.

16. The pacemaker of claim 11, wherein the rate response curve is a dual-slope curve, and the response factor changes from a low rate response factor to a high rate response factor at a heart rate breakpoint being a percentage of a difference between maximum and minimum sensor indicated rates defined by the rate response curve, and the microprocessor is configured to adjust the low rate response factor using the average maximum sensor indicated rate and the sensor target rate.

17. The pacemaker of claim 16, wherein the microprocessor is configured to adjust the high rate response factor such that the maximum exercise capacity is mapped to a specified maximum sensor indicated rate.

18. The pacemaker of claim 11, wherein the microprocessor is configured to:

update a maximum exercise capacity using the maximum exertion levels collected during the specified first period; and

adjust the response factor such that the updated maximum exercise capacity is mapped to a specified maximum sensor indicated rate.

19. The pacemaker of claim 18, wherein the microprocessor is configured to:

collect the maximum exertion levels for specified second periods during the specified first period; and

set the maximum exercise capacity to a maximum of the maximum exertion levels collected for the specified second periods during the specified first period.

20. The pacemaker of claim 19, wherein the specified second period is a day.