Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents

  • US 8,501,158 B2
  • Filed: 12/08/2010
  • Issued: 08/06/2013
  • Est. Priority Date: 04/09/1999
  • Status: Expired due to Fees
First Claim
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1. A method of treating a patient in need of an iron supplement, comprising intravenously administering to said patient a unit dose of an autoclaved pharmacological composition at a rate of about 1 mL/sec, wherein the composition comprises particles of a superparamagnetic iron oxide coated a carboxymethylasted reduced dextran having between about 1100 micromoles and about 1500 micromoles carboxyl per gram of carboxymethylated reduced dextran, wherein the reduced dextran has an average molecular weight of about 10 kDa, wherein the particles have a diameter between about 10 nm and 50 nm;

  • and whereinthe unit dose has about 500 mg to 600 mg of iron.

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