Methods and compositions for safe and effective treatment of erythema

  • US 8,513,247 B2
  • Filed: 03/25/2011
  • Issued: 08/20/2013
  • Est. Priority Date: 03/26/2010
  • Status: Active Grant
First Claim
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1. A method of treating erythema or a symptom associated therewith in a subject, comprising topically administering to a skin area affected by the erythema or the symptom a topical composition comprising, relative to the total weight of the composition, 0.4% to 0.6% by weight of brimonidine and a pharmaceutically acceptable carrier, wherein the topical administration results in more reduction of the erythema or the symptom compared to a vehicle control as measured by a 12 hour success profile evaluated on both Clinician'"'"'s Erythema Assessment scores and Patient'"'"'s Self Assessment scales without causing unacceptable drug related adverse events, and the 12 hour success profile comprises at least 1-grade improvement of the erythema or the symptom.

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