Methods and compositions for safe and effective treatment of erythema

  • US 8,513,249 B2
  • Filed: 04/26/2012
  • Issued: 08/20/2013
  • Est. Priority Date: 03/26/2010
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating erythema or a symptom associated therewith in a subject, comprising topically administering to a skin area affected by the erythema or the symptom a topical composition comprising, relative to the total weight of the composition, 0.4% to 0.6% by weight of brimonidine, and a pharmaceutically acceptable carrier, wherein the topical administration effects a serum or plasma profile of brimonidine having a mean Cmax of about 54±

  • 28 pg/mL or less and a mean AUC0-24 hr hr of about 568±

    277 or less.

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