Extracorperal ultrasonic irradition of titanium oxide (TiO2) coated implant for angiogenesis stimulation

• US 8,515,524 B2
• Filed: 12/01/2008
• Issued: 08/20/2013
• Est. Priority Date: 06/04/2008
• Status: Active Grant

• Current Assignee: National Cerebral And Cardiovascular Center
• Original Assignee: National Institute of Advanced Industrial Science and Technology (Government of Japan), National Cerebral And Cardiovascular Center
• Inventors: Furuzono, Tsutomu, Okada, Masahiro, Nitta, Naotaka, Yamane, Takashi, Masuda, Miwa
• Primary Examiner(s): Jung, Unsu
• Assistant Examiner(s): Akar, Serkan
• Application Number:
  US12/325,678
• Publication Number:
  US 20090306552A1
• Time in Patent Office: 1,723 Days
• Field of Search: 735/040.1, 310/129, 310/313, 428/701, 435/173.8, 435/289.1, 524/497, 524/588, 600/347, 600/365, 600/437, 601/46, 604/118, 604/175, 623/1.49, 702/19
• US Class Current: 600/407
• CPC Class Codes: A61B 90/40 Apparatus fixed or close to patients specially adapted for providing an aseptic surgical environment
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

The present invention solves the issue of bacterial infection by medical devices such as intracorporeal indwelling catheters. The present invention relates to an ultrasonic medical apparatus including a medical device (titanium oxide coated medical device 10) covered with a titanium oxide material (titanium oxide alone or a titanium oxide composite material) and ultrasonic irradiation means 20. Ultrasonic irradiation of the titanium oxide material, which exists on a surface of the medical device, causes the surface of the medical device to exert beneficial effects such as antibiotic action, the stimulation of angiogenesis, and the degradation of a blood clot and a biofilm.

Claims

1. A method of stimulating angiogenesis of a tissue in the vicinity of an implantable medical device by use of an ultrasonic medical apparatus including an ultrasonic irradiation means including a transducer, the method comprising the steps of:

implanting, into a body, the implantable medical device whose surface has been covered with a titanium oxide material; and

extracorporeally irradiating, by use of the ultrasonic irradiation means including the transducer, with ultrasonic waves, the titanium oxide material provided on the surface of the implantable medical device thus implanted,

the titanium oxide material being a titanium oxide composite material produced by covering a surface of a polymer base material with titanium oxide,

the titanium oxide composite material being composed of (a) a polymer base material having an active group and (b) titanium oxide having a reactive functional group capable of reacting with the active group, and

the titanium oxide composite material being produced through chemical bonding between the active group and the reactive functional group.

2. The method of stimulating angiogenesis as set forth in claim 1, wherein the irradiating by the ultrasonic irradiation means includes radiating ultrasonic waves with an output falling within safety standards for living organisms.

3. The method of stimulating angiogenesis as set forth in claim 1, further comprising adjusting the output of ultrasonic waves of the ultrasonic irradiation means.

4. The method of stimulating angiogenesis as set forth in claim 1, wherein the irradiating by the ultrasonic irradiation means includes generating one or more types of ultrasonic waves selected from the group consisting of continuous waves, pulse waves, burst waves, and standing waves.

5. The method of stimulating angiogenesis as set forth in claim 1, wherein the irradiating by the ultrasonic irradiation means includes radiating focused ultrasonic waves.

6. The method of stimulating angiogenesis as set forth in claim 1, wherein the ultrasonic irradiation means further includes a coupler.

7. The method of stimulating angiogenesis as set forth in claim 1,

wherein the transducer, which constitutes the ultrasonic irradiation means, is composed of a piezoelectric substance having a coefficient of electromechanical coupling of not less than 10%.

8. The method of stimulating angiogenesis as set forth in claim 7, wherein the transducer, which constitutes the ultrasonic irradiation means, is composed of a piezoelectric substance that is a quartz crystal, a water-soluble crystal, a piezoceramic, a polymer piezoelectric material, a highly-bound piezoelectric material, a composite piezoelectric material, an electrodeposited piezoelectric material, or any combination of the materials.

9. The method of stimulating angiogenesis as set forth in claim 1, wherein the irradiating by the ultrasonic irradiation means includes generating ultrasonic waves at a frequency of not less than 150 kHz.

10. The method of stimulating angiogenesis as set forth in claim 1, wherein the irradiating by the ultrasonic irradiation means includes generating, in a single transmission, ultrasonic waves containing higher harmonic waves or multi-frequency waves.

11. The method of stimulating angiogenesis as set forth in claim 1, wherein the reactive functional group is an amino group.

12. The method of stimulating angiogenesis as set forth in claim 1, wherein the reactive functional group is a hydroxyl group.

13. The method of stimulating angiogenesis as set forth in claim 1, wherein the titanium oxide composite material satisfies either or both of the following conditions (i) and (ii):

(i) the titanium oxide composite material is composed of (a) the polymer base material having the active group and (b) the titanium oxide having the reactive functional group, wherein the reactive functional group is an amino group, and is produced through chemical bonding between the active group and the amino group; and

(ii) the titanium oxide composite material is produced through chemical bonding between the reactive functional group possessed by titanium oxide, wherein the reactive functional group is a hydroxyl group, and the active group, possessed by a polymer base material, which is capable of forming the chemical bond with the hydroxyl group.

14. The method of stimulating angiogenesis as set forth in claim 1, wherein the medical device surface has been covered with the titanium oxide material by flocking.