Compositions and methods for inhibiting EZH2

• US 8,524,682 B2
• Filed: 05/12/2010
• Issued: 09/03/2013
• Est. Priority Date: 07/03/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Chinnaiyan, Arul M., Lnu, Sooryanarayana, Cao, Qi
• Primary Examiner(s): WHITEMAN, BRIAN A
• Application Number:
  US12/778,739
• Publication Number:
  US 20100222420A1
• Time in Patent Office: 1,210 Days
• Field of Search: 514/44.A
• US Class Current: 514/44.A
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.

Claims

1. A method of inhibiting the growth of cells, comprising contacting a cancer cell selected from the group consisting of a prostate cancer cell, a breast cancer cell, and bladder cancer cell overexpressing EZH2 with miR-101 under conditions such that the expression of EZH2 in said cancer cell is inhibited.

2. The method of claim 1, wherein said cell is in an organism.

3. The method of claim 2, wherein said organism is an animal.

4. The method of claim 3, wherein said animal has been diagnosed with cancer.