Device and method for determining analyte levels

• US 8,527,026 B2
• Filed: 03/02/2012
• Issued: 09/03/2013
• Est. Priority Date: 03/04/1997
• Status: Expired due to Fees

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Shults, Mark C., Updike, Stuart J., Rhodes, Rathbun K., Gilligan, Barbara J., Tapsak, Mark A.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US13/411,414
• Publication Number:
  US 20120179014A1
• Time in Patent Office: 550 Days
• Field of Search: 600/345, 600/347, 600/365
• US Class Current: 600/347
• CPC Class Codes: A61B 2562/17 Comprising radiolucent components
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Claims

1. An implantable sensor for measuring glucose, the sensor comprising:

an electrode configured to measure glucose; and

a membrane disposed on at least a portion of the electrode, the membrane comprising a first domain that comprises polyurethane and polyvinylpyrrolidone and a second domain that comprises an enzyme, wherein the first domain is configured to allow transport of glucose and oxygen and prevent entry of inflammatory cells, and wherein the first domain is distal to the second domain with respect to the electrode.

2. The sensor of claim 1, wherein the polyurethane is polycarbonateurethane.

3. The sensor of claim 1, wherein the first domain further comprises at least one material selected from the group consisting of polytetrafluoroethylene, polypropylene, polysulfone, and polyethylene terephthalate.

4. The sensor of claim 1, wherein the enzyme is glucose oxidase.