Use of 1 phenyl-3-dimethylamino-propane compounds for treating neuropathic pain

• US 8,536,130 B2
• Filed: 08/04/2010
• Issued: 09/17/2013
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Original Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Inventors: Christoph, Thomas, Friderichs, Elmar, Koegel, Babette-Yvonne, Meen, Murielle
• Primary Examiner(s): RAO, SAVITHA M
• Application Number:
  US12/850,208
• Publication Number:
  US 20100311842A1
• Time in Patent Office: 1,140 Days
• Field of Search: 514/18.2, 514/529, 514/646, 514/452, 514/456, 514/434
• US Class Current: 514/18.2
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/02 for peripheral neuropathies
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy.

Claims

1. A method of treating polyneuropathic pain in a subject suffering therefrom, said method comprising administering to said subject an effective polyneuropathic pain inhibiting amount of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol

or a pharmaceutically acceptable salt thereof.

2. A method according to claim 1, comprising administering a hydrochloride salt of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol.

3. A method according to claim 1, wherein said polyneuropathic pain is diabetic polyneuropathic pain.

4. A method according to claim 1, wherein said polyneuropathic pain is peripheral polyneuropathic pain.

5. A method according to claim 1, wherein said polyneuropathic pain is peripheral diabetic polyneuropathic pain.

6. A method of treating diabetic polyneuropathy in a subject suffering therefrom, said method comprising administering to said subject a pharmacologically effective amount of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol

or a pharmaceutically acceptable salt thereof.