Enhancing perfusion by contraction

• US 8,538,535 B2
• Filed: 08/05/2010
• Issued: 09/17/2013
• Est. Priority Date: 08/05/2010
• Status: Expired due to Fees

• Current Assignee: Enopace Biomedical Ltd.
• Original Assignee: Rainbow Medical Ltd.
• Inventors: Gross, Yossi, Dagan, Amir, Reisner, Yotam, Glasberg, Offer, Hanani, Nitai, Ariav, Gal
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US12/851,214
• Publication Number:
  US 20120035711A1
• Time in Patent Office: 1,139 Days
• Field of Search: 607/44
• US Class Current: 607/44
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0514 Electrodes for the urinary tract
• CPC Class Codes: A61N 1/0521 Genital electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

Apparatus and methods are described including a mechanical support element that is placed inside a first vein of a subject. At least one electrode disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

Claims

1. A method, comprising:

enhancing perfusion of an organ that is upstream of a site of a first vein of a subject, the site of the first vein being upstream of a bifurcation of the first vein with a second vein of the subject, by;

driving a first electric current into the site of the first vein, via an electrode disposed on a mechanical support element;

configuring the electric current to divert blood in a downstream direction, into the second vein, by constricting the first vein at the upstream site,

the mechanical support element being configured, subsequent to the constricting of the vein, to enhance perfusion of the organ, by causing the vein to fill with blood, by causing the vein to expand.

2. The method according to claim 1, wherein driving the current comprises driving the current into first and second sites of the first vein via respective first and second electrodes, the first and second sites being on contralateral sides of the first vein.

3. The method according to claim 1, wherein configuring the current comprises configuring the current to divert blood into the second vein by generating a peristaltic wave of constriction in a downstream direction, along the wall of the first vein, toward the bifurcation.

4. The method according to claim 1, wherein driving the electric current comprises sensing a level of blood pressure of the subject and driving the electric current in response to the sensed level of blood pressure of the subject.

5. The method according to claim 4, wherein configuring the current comprises identifying when the level of the blood pressure is lower than a designated threshold blood pressure level, and regulating the current in response thereto.

6. The method according to claim 1, wherein driving the electric current comprises driving the electric current via a set of one or more electrodes that are implanted at the upstream site.

7. The method according to claim 6, wherein driving the electric current comprises driving the electric current via a set of one or more electrodes that are chronically implanted at the upstream site.

8. The method according to claim 6, wherein the mechanical support element includes a wire frame to which the set of one or more electrodes are coupled and wherein driving the electric current comprises driving the electric current via the set of one or more electrodes that are coupled to the wire frame.

9. The method according to claim 1, wherein driving the electric current comprises driving the current irrespective of a phase of a cardiac cycle of the subject.