Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders
First Claim
1. A method for treating a patient'"'"'s neurological disorder, comprising:
- in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient'"'"'s skull cavity, outside a cortical surface of the patient'"'"'s brain, and at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned (a) at the precentral sulcus and (b) at the patient'"'"'s middle frontal gyrus; and
treating the patient'"'"'s disorder by applying electrical stimulation to the patient via the at least one stimulation electrode;
wherein;
the at least one stimulation electrode is one of a plurality of stimulation electrodes;
all of the active stimulation electrodes implanted within the patient'"'"'s skull cavity are implanted outside the cortical surface of the patient'"'"'s brain at the patient'"'"'s middle frontal gyrus;
the at least one electrode is the posterior-most electrode within the patient'"'"'s skull cavity and outside a cortical surface of the patient'"'"'s brain via which electrical stimulation is applied to the patient'"'"'s brain;
the at least one electrode is at least 18 mm anterior to the precentral sulcus reference point and is positioned superior to a linear or curvilinear line that at least bisects the middle frontal ayrus into a superior portion and an inferior portion; and
the precentral sulcus reference point is approximately at an intersection of the precentral sulcus and the linear or curvilinear line.
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Accused Products
Abstract
Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient'"'"'s neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient'"'"'s skull cavity, and outside a cortical surface of the patient'"'"'s brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient'"'"'s middle frontal gyrus. The method can further include treating the patient'"'"'s disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
139 Citations
18 Claims
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1. A method for treating a patient'"'"'s neurological disorder, comprising:
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in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient'"'"'s skull cavity, outside a cortical surface of the patient'"'"'s brain, and at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned (a) at the precentral sulcus and (b) at the patient'"'"'s middle frontal gyrus; and treating the patient'"'"'s disorder by applying electrical stimulation to the patient via the at least one stimulation electrode; wherein; the at least one stimulation electrode is one of a plurality of stimulation electrodes; all of the active stimulation electrodes implanted within the patient'"'"'s skull cavity are implanted outside the cortical surface of the patient'"'"'s brain at the patient'"'"'s middle frontal gyrus; the at least one electrode is the posterior-most electrode within the patient'"'"'s skull cavity and outside a cortical surface of the patient'"'"'s brain via which electrical stimulation is applied to the patient'"'"'s brain; the at least one electrode is at least 18 mm anterior to the precentral sulcus reference point and is positioned superior to a linear or curvilinear line that at least bisects the middle frontal ayrus into a superior portion and an inferior portion; and the precentral sulcus reference point is approximately at an intersection of the precentral sulcus and the linear or curvilinear line. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for treating a patient'"'"'s neurological disorder, comprising:
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in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, preferentially directing electrical stimulation to a target location of the patient'"'"'s brain, the target location being in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned (a) at the precentral sulcus and (b) at the patient'"'"'s middle frontal gyrus, with the electrical stimulation being directed from at least one stimulation electrode positioned within the patient'"'"'s skull cavity and outside a cortical surface of the patient'"'"'s brain; wherein; the at least one stimulation electrode is one of a plurality of stimulation electrodes; all of the stimulation electrodes within the patient'"'"'s skull cavity are outside the cortical surface of the patient'"'"'s brain at the patient'"'"'s middle frontal gyrus; the at least one electrode is the posterior-most electrode within the patient'"'"'s skull cavity and outside a cortical surface of the patient'"'"'s brain via which electrical stimulation is applied to the patient'"'"'s brain; the at least one electrode is at least 18 mm anterior to the precentral sulcus reference point and is positioned superior to a linear or curvilinear line that at least bisects the middle frontal gyrus into a superior portion and an inferior portion; and the precentral sulcus reference point is approximately at an intersection of the precentral sulcus and the linear or curvilinear line. - View Dependent Claims (15, 16, 17, 18)
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Specification