Silicone based membranes for use in implantable glucose sensors

  • US 8,543,184 B2
  • Filed: 10/20/2011
  • Issued: 09/24/2013
  • Est. Priority Date: 05/22/2002
  • Status: Active Grant
First Claim
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1. A transcutaneous implantable continuous analyte sensor, comprising:

  • a working electrode configured to be transcutaneously implanted; and

    a membrane disposed over at least a portion of the working electrode, the membrane comprising a blend, the blend comprising a silicone-containing polymer and a hydrophilic polymer;

    wherein the membrane is configured to reduce or block passage therethrough of acetaminophen, whereby when;

    (1) the sensor is placed in a 2L bath filled with phosphate buffered saline, continuously stirred, brought to a temperature of 37°

    C., allowed to equilibrate for 1 hour until the sensor reaches a flat line continuous baseline signal; and

    (2) acetaminophen is then added to the bath to a dilution of 3.8 mg/dL and the sensor is then allowed to equilibrate over 1 hour while measurements are continuously recorded from the sensor;

    the signal does not change by more than 1%.

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