Implantable systems and methods for identifying a contra-ictal condition in a subject

• US 8,543,199 B2
• Filed: 09/02/2011
• Issued: 09/24/2013
• Est. Priority Date: 03/21/2007
• Status: Active Grant

• Current Assignee: Cyberonics, Inc
• Original Assignee: Cyberonics, Inc
• Inventors: Snyder, David, Leyde, Kent W., Harris, John F.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US13/225,241
• Publication Number:
  US 20110319785A1
• Time in Patent Office: 753 Days
• Field of Search: 600/479, 600/473, 600/310, 600/323, 600/324, 600/481, 600/500, 600/502, 600/504, 600/507
• US Class Current: 600/544
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period

Abstract

Systems and methods of monitoring a subject'"'"'s neurological condition are provided. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition. The systems and methods may utilize a minimally invasive, leadless device to monitor the subject'"'"'s condition. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition.

Claims

1. A neurological monitoring system comprising:

an implantable device; and

an external transmission assembly configured to deliver power to the implantable device and to receive a wireless data signal from the implantable device,

the implantable device comprising a processing assembly for sampling a neurological signal from a subject, a power assembly for receiving power from the external transmission assembly, and a communication assembly for transmitting the wireless data signal from within a subject'"'"'s body to the external transmission assembly, said wireless data signal being encoded with data indicative of the sampled neurological signal,

the processing assembly being configured to process the wireless data signal from the implantable device to determine if the subject is in a contra-ictal condition, said contra-ictal condition being a neurological state in which the subject is unlikely to transition into an ictal condition within a time period.

2. The neurological monitoring system of claim 1, further comprising a user interface configured to provide an output to the subject that indicates that the subject is in the contra-ictal condition.

3. The neurological monitoring system of claim 2, further comprising a subject advisory device comprising the external transmission assembly, the processing assembly, and the user interface.

4. The neurological monitoring system of claim 3, wherein the subject advisory device comprises a memory for storing the data indicative of the sampled neurological signal.

5. The neurological monitoring system of claim 1, wherein the external transmission assembly is configured to deliver power to the implantable device via electromagnetic induction.

6. The neurological monitoring system of claim 5, wherein the external transmission assembly is configured to receive the wireless data signal from the implantable device via electromagnetic induction.

7. The neurological monitoring system of claim 5, wherein the external transmission assembly is configured to receive the wireless data signal from the implantable device via an RF link.

8. The neurological monitoring system of claim 1, wherein the external transmission assembly is configured to receive the wireless data signal from the implantable device via an RF link.

9. The neurological monitoring system of claim 1, wherein the external transmission assembly is configured to simultaneously deliver power to the implantable device and receive the wireless data signal from the implantable device.

10. The neurological monitoring system of claim 1, wherein the wireless data signal includes a heart rate signal.

11. The neurological monitoring system of claim 1, wherein the wireless data signal includes a respiratory signal.

12. The neurological monitoring system of claim 1, wherein the wireless data signal corresponds to at least one of a blood pressure, a blood oxygenation, a temperature, a blood flow, an ECG, an EKG, a chemical concentration of a neurotransmitter, a chemical concentration of a medication, and a pH in the blood.

13. The neurological monitoring system of claim 1, wherein the processing assembly is adapted to determine if the subject is in a contra-ictal condition by:

extracting N features from the sampled neurological signal;

generating a N-dimensional feature vector of the extracted N features for time points of the sampled neurological signal; and

determining if the N-dimensional feature vector is within a contra-ictal cluster or region in the N-dimensional space.

14. The neurological monitoring system of claim 1, wherein the neurological signal is an EEG signal.

15. A method of monitoring neurological signals from a subject, said method comprising:

delivering power from an external transmission assembly to an implanted device;

sampling a neurological signal from the subject with the implanted device;

transmitting a wireless data signal from within the subject'"'"'s body to the external transmission assembly, said wireless data signal being encoded with data indicative of the sampled neurological signal; and

analyzing the neurological signal from the subject using a processor to determine if the subject is in a contra-ictal condition, said contra-ictal condition being a neurological state in which the subject is unlikely to transition into an ictal condition within a time period.

16. The method of claim 15, wherein the wireless data signal includes a respiratory signal.

17. The method of claim 15, wherein the wireless data signal corresponds to at least one of a blood pressure, a blood oxygenation, a temperature, a blood flow, an ECG, an EKG, a chemical concentration of a neurotransmitter, a chemical concentration of a medication, and a pH in the blood.

18. The method of claim 15, wherein the wireless data signal includes a heart rate signal.

19. The method of claim 15, wherein said delivering power from the external transmission assembly to the implanted device comprises delivering power from the external transmission assembly to the implanted device via electromagnetic induction.

20. The method of claim 19, wherein said transmitting the wireless data signal from within the subject'"'"'s body to the external transmission assembly comprises transmitting the wireless data signal from within the subject'"'"'s body to the external transmission assembly via electromagnetic induction.

21. The method of claim 19, wherein said transmitting the wireless data signal from within the subject'"'"'s body to the external transmission assembly comprises transmitting the wireless data signal from within the subject'"'"'s body to the external transmission assembly via an RF link.

22. The method of claim 15, wherein said transmitting the wireless data signal from within the subject'"'"'s body to the external transmission assembly comprises transmitting the wireless data signal from within the subject'"'"'s body to the external transmission assembly via an RF link.

23. The method of claim 15, wherein said delivering power from the external transmission assembly is performed at the same time as said transmitting the wireless data signal.

24. The method of claim 15, wherein the analyzing the neurological signal comprises:

extracting N features from the sampled neurological signal;

generating a N-dimensional feature vector of the extracted N features for time points of the sampled neurological signal; and

determining if the N-dimensional feature vector is within a contra-ictal cluster or region in the N-dimensional space.

25. The method of claim 15, wherein the neurological signal is an EEG signal.

26. A neurological monitoring system comprising:

an implantable device;

an external transmission assembly configured to receive a wireless data signal from the implantable device; and

a processing assembly for sampling a signal from a subject,

wherein the implantable device includes a power assembly for receiving power from the external transmission assembly and a communication assembly for transmitting the wireless data signal from within a subject'"'"'s body to the external transmission assembly, said wireless data signal being encoded with data indicative of the sampled signal, and

wherein the processing assembly is configured to process the wireless data signal from the implantable device to determine if the subject is in a contra-ictal condition, said contra-ictal condition being a neurological state in which the subject is unlikely to transition into an ictal condition within a time period.

27. The neurological monitoring system of claim 26, wherein the wireless data signal includes a heart rate signal.

28. The neurological monitoring system of claim 26, wherein the wireless data signal includes a respiratory signal.

29. The neurological monitoring system of claim 26, wherein the wireless data signal corresponds to at least one of a blood pressure, a blood oxygenation, a temperature, a blood flow, an ECG, an EKG, a chemical concentration of a neurotransmitter, a chemical concentration of a medication, and a pH in the blood.

30. A method of monitoring signals from a subject, said method comprising:

delivering power to an implanted device;

sampling a signal from the subject with the implanted device;

transmitting a wireless data signal from within the subject'"'"'s body to an external transmission assembly, said wireless data signal being encoded with data indicative of the sampled signal; and

analyzing the sampled signal from the subject using a processor to determine if the subject is in a contra-ictal condition, said contra-ictal condition being a neurological state in which the subject is unlikely to transition into an ictal condition within a time period.

31. The method of claim 30, wherein the wireless data signal includes a heart rate signal.

32. The method of claim 30, wherein the wireless data signal includes a respiratory signal.

33. The method of claim 30, wherein the wireless data signal corresponds to at least one of a blood pressure, a blood oxygenation, a temperature, a blood flow, an ECG, an EKG, a chemical concentration of a neurotransmitter, a chemical concentration of a medication, and a pH in the blood.