Glucose sensor signal stability analysis
First Claim
1. A method comprising:
- obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;
determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and
assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend,wherein said assessing further comprises;
assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold;
assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and
assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.
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Accused Products
Abstract
Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.
111 Citations
22 Claims
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1. A method comprising:
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obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said assessing further comprises; assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold; assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold. - View Dependent Claims (2, 3, 4, 5)
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6. A method comprising:
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obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said assessing further comprises; comparing the at least one metric assessing the underlying trend with at least a first predetermined threshold and a second predetermined threshold; and ascertaining at least one value indicating a severity of divergence by the at least one sensor signal from the blood glucose level of the patient over time based at least partly on the at least one metric assessing the underlying trend, the first predetermined threshold, and the second predetermined threshold.
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7. A method comprising:
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obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; transforming the series of samples of the at least one sensor signal to derive a monotonic curve; determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time, the at least one metric assessing the underlying trend being produced using a slope of a linear regression that is derived at least partly from the series of samples of the at least one sensor signal, the linear regression being derived at least partly from the monotonic curve; and assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend.
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8. A method comprising:
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obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time by decomposing the at least one sensor signal as represented by the series of samples using at least one empirical mode decomposition and one or more spline functions to remove relatively higher frequency components from the at least one sensor signal; and assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend.
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9. A method comprising:
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obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said determining comprises; decomposing the at least one sensor signal as represented by the series of samples using at least one discrete wavelet transform; and
reconstructing a smoothed signal from one or more approximation coefficients resulting from the at least one discrete wavelet transform.
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10. A method comprising:
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obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said determining comprises;
iteratively updating a trend estimation at multiple samples of the series of samples of the at least one sensor signal based at least partly on a trend estimation at a previous sample and a growth term.
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11. An apparatus comprising:
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a controller to obtain a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient, said controller comprising one or more processors to; determine, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and assess a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend by; comparing the at least one metric assessing the underlying trend with at least a first predetermined threshold and a second predetermined threshold; assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold; assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and the second predetermined threshold; and assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system comprising:
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means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend, wherein said means for assessing said reliability of the at least one sensor signal to respond to the blood glucose level further comprises; means for assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold; means for assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and means for assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.
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22. An article comprising:
at least one storage medium having stored thereon instructions executable by one or more processors to; obtain a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient; determine, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and assess a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend by; assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold; assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.
Specification