Inhaled hypertonic saline delivered by a heated nasal cannula
First Claim
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1. A method of treating chronic obstructive pulmonary disease, comprising:
- producing an effective amount of an aerosolized osmolyte with a nebulizer; and
delivering the aerosolized osmolyte continuously over a period of at least eight hours via a nasal cannula configured to limit accumulation of liquid droplets therein.
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Abstract
The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
187 Citations
27 Claims
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1. A method of treating chronic obstructive pulmonary disease, comprising:
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producing an effective amount of an aerosolized osmolyte with a nebulizer; and delivering the aerosolized osmolyte continuously over a period of at least eight hours via a nasal cannula configured to limit accumulation of liquid droplets therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method, comprising:
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delivering a flow of a gas to nebulizer system via a gas input port; producing an aerosolized osmolyte within the nebulizer system; and delivering the flow of gas and the aerosolized osmolyte continuously over a period of at least eighty minutes via a nasal cannula, the nasal cannula configured to limit accumulation of liquid droplets therein. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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21. A method, comprising:
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delivering a flow of a gas to a nebulizer system via a gas input port; producing an aerosolized osmolyte within the nebulizer system; and delivering the flow of gas and the aerosolized osmolyte via a nasal cannula, the nasal cannula including a tube having a length of at least two meters, an end portion of the tube coupled to the nebulizer system, the nasal cannula configured to limit accumulation of liquid droplets therein. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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Specification