Preparation of azoxystrobin

• US 8,552,185 B2
• Filed: 10/02/2007
• Issued: 10/08/2013
• Est. Priority Date: 10/09/2006
• Status: Active Grant

• Current Assignee: Syngenta Limited (China National Chemical Corporation)
• Original Assignee: Syngenta Limited (China National Chemical Corporation)
• Inventors: Boyd, Ewan Campbell, Whitton, Alan John, Beveridge, Gillian, Vass, Jack Hugh
• Primary Examiner(s): RAO, DEEPAK R
• Application Number:
  US12/444,896
• Publication Number:
  US 20100036124A1
• Time in Patent Office: 2,198 Days
• Field of Search: 544/319
• US Class Current: 544/319
• CPC Class Codes: C07D 239/34 One oxygen atom

Abstract

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using, as a catalyst 1,4-diazabicyclo[2.2.2]octane.

Claims

1. A process for preparing a compound of formula (I):

2. The process according to claim 1 which is carried out in the presence of between 0.5 and 5 mol % of 1,4-diazabicyclo[2.2.2]octane.

3. The process according to claim 1 which is carried out in an inert solvent or diluent.

4. The process according to claim 3 in which the inert solvent or diluent is methyl isobutyl ketone, cyclohexanone, N,N-diisopropylethylamine, toluene, isopropyl acetate or N,N-dimethylformamide.

5. The process according to claim 4 in which the inert solvent or diluent is N,N-dimethylformamide.

6. The process according to claim 1 which is carried out in an aqueous organic solvent system.

7. The process according to claim 6, wherein the organic solvent is cyclohexanone, methyl isobutyl ketone, isopropyl acetate, or N,N-dimethylformamide.

8. The process according to claim 6 wherein, as a salt of 2-cyanophenol, potassium 2-cyanophenoxide is used.

9. The process according to claim 1 which is carried out in the presence of an acid acceptor.

10. The process according to claim 9 in which the acid acceptor is potassium carbonate or sodium carbonate.

11. The process according to claim 1 which is carried out at a temperature of from 0 to 120°

C.