Controlled release formulations of levodopa and uses thereof

  • US 8,557,283 B2
  • Filed: 12/11/2012
  • Issued: 10/15/2013
  • Est. Priority Date: 12/28/2007
  • Status: Active Grant
First Claim
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1. A method of reducing motor fluctuations in a patient suffering from Parkinson'"'"'s disease comprising administering to the patient an effective amount of a controlled release oral solid formulation of levodopa comprising:

  • (a) levodopa;

    (b) a decarboxylase inhibitor; and

    (c) a carboxylic acid that is not (a) or (b);

    wherein the carboxylic acid of (c) is in a distinct bead from (a) or (b) thereby providing a plasma concentration of levodopa effective to reduce motor fluctuations in the patient.

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