Genetically modified rat comprising a cytokine gene disruption and exhibiting a greater susceptibility to a cytokine-mediated autoimmune and/or inflammatory disease

  • US 8,558,055 B2
  • Filed: 07/23/2010
  • Issued: 10/15/2013
  • Est. Priority Date: 07/24/2009
  • Status: Active Grant
First Claim
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1. A genetically modified rat or progeny of the rat, wherein the rat or its progeny comprise in at least some of its cells a genome comprising a disruption of one or more cytokine genes that results in the misexpression of the one or more cytokine genes, wherein the rat or its progeny exhibits a greater susceptibility to a cytokine-mediated autoimmune and/or inflammatory disease than a rat or progeny rat not comprising the genetic mutation.

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