Diclofenac topical formulation

CAFC
  • US 8,563,613 B2
  • Filed: 08/01/2012
  • Issued: 10/22/2013
  • Est. Priority Date: 10/17/2006
  • Status: Active Grant
First Claim
Patent Images

1. A topical formulation comprising:

  • (i) 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, or 5.0% w/w and all fractions in between, diclofenac sodium;

    (ii) 30-60% w/w DMSO;

    (iii) 1-15% w/w propylene glycol;

    (iv) 1-30% w/w ethanol;

    (v) optionally glycerine;

    (vi) water;

    (vii) at least one thickening agent selected from the group consisting of acellulose polymer, a carbomer polymer, a carbomer derivative, a cellulose derivative, and mixtures thereof;

    wherein the topical formulation has a viscosity of 500-5000 centipoise; and

    wherein the formulation degrades by less than 1% over 6 months.

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