Arousal state modulation with electrical stimulation
First Claim
1. A method comprising:
- receiving, from a sensing module, a bioelectrical brain signal indicative of electrical activity in a first portion of a brain of a patient;
determining, with a processor, that the brain of the patient is in a first arousal state based on the bioelectrical brain signal, wherein determining that the brain of the patient is in the first arousal state comprises detecting a biomarker indicative of the first arousal state based on the bioelectrical brain signal; and
controlling, with the processor, a stimulation module to deliver electrical stimulation to a second portion of the brain of the patient that is different than the first portion in response to determining that the first portion of the brain of the patient is in the first arousal state, wherein the electrical stimulation is configured to activate an arousal neural network in the first portion of the brain of the patient to induce a second arousal state in the brain of the patient, wherein the first portion of the brain of the patient exhibits a higher amount of electrical activity in the second arousal state than in the first arousal state, and wherein the electrical stimulation is configured to treat a cognitive disorder of the patient.
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Accused Products
Abstract
In some examples, an arousal network of a brain of a patient can be activated to modify the arousal state of the patient, which may be useful in treating a cognitive disorder of the patient. In some examples, a bioelectrical brain signal indicative of electrical activity in a first portion of the brain is monitored to determine whether the patient is in a first arousal state, and, in response to determining the patient is in the first arousal state, electrical stimulation is delivered to a second portion of the brain to activate an arousal neural network in the first portion of the brain to induce a second arousal state to treat the cognitive disorder, where the second arousal state is different than the first arousal state.
71 Citations
34 Claims
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1. A method comprising:
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receiving, from a sensing module, a bioelectrical brain signal indicative of electrical activity in a first portion of a brain of a patient; determining, with a processor, that the brain of the patient is in a first arousal state based on the bioelectrical brain signal, wherein determining that the brain of the patient is in the first arousal state comprises detecting a biomarker indicative of the first arousal state based on the bioelectrical brain signal; and controlling, with the processor, a stimulation module to deliver electrical stimulation to a second portion of the brain of the patient that is different than the first portion in response to determining that the first portion of the brain of the patient is in the first arousal state, wherein the electrical stimulation is configured to activate an arousal neural network in the first portion of the brain of the patient to induce a second arousal state in the brain of the patient, wherein the first portion of the brain of the patient exhibits a higher amount of electrical activity in the second arousal state than in the first arousal state, and wherein the electrical stimulation is configured to treat a cognitive disorder of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A system comprising:
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a sensing module configured to sense a bioelectrical brain signal indicative of electrical activity in a first portion of a brain of a patient; a processor configured to determine that the brain of the patient is in a first arousal state based on the bioelectrical brain signal, wherein the processor is configured to determine that the brain of the patient is in the first arousal state by at least detecting a biomarker indicative of the first arousal state based on the bioelectrical brain signal; and a stimulation generator configured to generate and deliver electrical stimulation to a second portion of the brain of the patient that is different than the first portion, wherein the processor is configured to control the stimulation generator to deliver electrical stimulation to the second portion of the brain of the patient in response to determining that the first portion of the brain of the patient is in the first arousal state, wherein the electrical stimulation is configured to activate an arousal neural network in the first portion of the brain of the patient to induce a second arousal state in the brain of the patient, wherein the first portion of the brain of the patient exhibits a higher amount of electrical activity in the second arousal state than in the first arousal state, and wherein the electrical stimulation is configured to treat a cognitive disorder of the patient. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A non-transitory computer-readable medium comprising instructions that cause a programmable processor to:
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receive, from a sensing module, a bioelectrical brain signal indicative of electrical activity in a first portion of a brain of a patient; determine that the brain of the patient is in a first arousal state based on the bioelectrical brain signal by at least detecting a biomarker indicative of the first arousal state based on the bioelectrical brain signal; and control a stimulation generator to deliver electrical stimulation to a second portion of the brain of the patient in response to determining that the first portion of the brain of the patient is in the first arousal state, wherein the electrical stimulation is configured to activate an arousal neural network in the first portion of the brain of the patient to induce a second arousal state in the brain of the patient, wherein the first portion of the brain of the patient exhibits a higher amount of electrical activity in the second arousal state than in the first arousal state, and wherein the electrical stimulation is configured to treat a cognitive disorder of the patient. - View Dependent Claims (30, 31)
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32. A system comprising:
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means for receiving a bioelectrical brain signal indicative of electrical activity in a first portion of a brain of a patient; means for determining that the brain of the patient is in a first arousal state based on the bioelectrical brain signal, wherein the means for determining that the brain of the patient is in a first arousal state based on the bioelectrical brain signal comprises means for detecting a biomarker indicative of the first arousal state based on the bioelectrical brain signal; and means for controlling delivery of electrical stimulation to a second portion of the brain of the patient that is different than the first portion in response to determining that the first portion of the brain of the patient is in the first arousal state, wherein the electrical stimulation is configured to activate an arousal neural network in the first portion of the brain of the patient to induce a second arousal state in the brain of the patient, wherein the first portion of the brain of the patient exhibits a higher amount of electrical activity in the second arousal state than in the first arousal state, and wherein the electrical stimulation is configured to treat a cognitive disorder of the patient. - View Dependent Claims (33, 34)
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Specification