Systems and methods for enabling heart valve replacement

• US 8,568,473 B2
• Filed: 12/15/2006
• Issued: 10/29/2013
• Est. Priority Date: 12/15/2005
• Status: Active Grant

• Current Assignee: Georgia Tech Research Corporation (University System of Georgia)
• Original Assignee: Georgia Tech Research Corporation (University System of Georgia)
• Inventors: Yoganathan, Ajit P., Jimenez, Jorge Hernan
• Primary Examiner(s): ANDERSON, GREGORY A
• Application Number:
  US12/097,173
• Publication Number:
  US 20090157174A1
• Time in Patent Office: 2,510 Days
• Field of Search: 623/1.24, 623/1.26, 623/2.1, 623/2.11, 623/2.17, 623/2.38
• US Class Current: 623/2.11
• CPC Class Codes: A61F 2/2409 Support rings therefor, e.g. for connecting valves to tissue annuloplasty rings A61F2/2442
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2002/8483 Barbs
• CPC Class Codes: A61F 2002/9528 for retrieval of stents
• CPC Class Codes: A61F 2250/0059 temporary
• CPC Class Codes: A61F 2250/006 modular

Abstract

The present invention describes a cardiac prosthetic system (400) comprising: an anchoring conduit (200) having a harbor (415), the harbor including a first releasably engaging component (515); a temporary valve (305) and a heart valve prosthesis (420) having a second releasably engaging component (445) enabled to be securely coupled and uncoupled from the first releasably engaging component (515) of the harbor (415).

Claims

1. A method of preparing a heart valve for replacement comprising:

delivering an anchoring conduit to a heart valve, the anchoring conduit comprising an expandable structure having an outer layer and an inner layer, the outer layer configured to bend to conform to the contour of a tissue component and the inner layer comprising a smooth and substantially uniform inner surface;

wherein the expansion of the expandable structure enables the expandable structure to interface with the tissue component and define an open cavity, the open cavity defined at least in part by the inner layer having the smooth and substantially uniform inner surface;

wherein the anchoring conduit includes a harbor enabled to releasably connect a heart valve prosthesis; and

expanding the anchoring conduit in the heart valve.

2. The method of preparing a heart valve for replacement of claim 1 further comprising:

delivering a temporary valve, in a condensed state, to a target site proximate the heart valve; and

deploying the temporary valve at the target site proximate the heart valve; and

wherein the temporary valve operates to temporarily replace the function of the heart valve when the anchoring conduit is expanded.

3. The method of preparing a heart valve for replacement of claim 1, wherein the open cavity of the anchoring conduit provides an inner lumen surface against which a heart valve prosthesis can be deployed.

4. The method of preparing a heart valve for replacement of claim 1, wherein the inner surface of the open cavity includes a biocompatible lumen.

5. An anchoring conduit comprising:

an expandable structure having an outer layer and an inner layer, the outer layer configured to bend to conform to the contour of a tissue component and the inner layer comprising a smooth and substantially uniform inner surface;

wherein the expansion of the expandable structure enables the expandable structure to interface with the tissue component and define an open cavity, the open cavity defined at least in part by the inner layer having the smooth and substantially uniform inner surface; and

wherein the anchoring conduit, further comprises a harbor in communication with the expandable structure, the harbor including a first releasably engaging component.

6. The anchoring conduit of claim 5, wherein the anchoring conduit further comprises an anchoring component configured to disable a heart valve.

7. The anchoring conduit of claim 5, wherein the anchoring conduit further comprises an anchoring component configured to disable a native heart valve by compressing the components of the native heart valve against the native heart valve.

8. The anchoring conduit of claim 5, wherein an anchoring component is configured to receive a heart valve prosthesis.

9. The anchoring conduit of claim 8, wherein the expandable structure is configured to enable tissue growth onto the heart valve prosthesis.

10. The anchoring conduit of claim 5, wherein an anchoring component is enabled to be endovascularly delivered.

11. The anchoring conduit of claim 5, wherein a heart valve prosthesis having a second releasably engaging component is enabled to be securely coupled and uncoupled from the first releasably engaging component of the harbor.

12. The anchoring conduit of claim 11, wherein the heart valve prosthesis can be coupled and uncoupled from the first releasably engaging component of the harbor within the heart.

13. The anchoring conduit of claim 5, wherein the expandable structure is configured to contain a plurality of debris released from the tissue component.

14. The anchoring conduit of claim 5, wherein the expandable structure is configured to expand and adapt to the geometry of the sinuses of the valsalva.

15. The anchoring conduit of claim 5, wherein the anchoring conduit can be delivered through the apex of a heart.

16. The anchoring conduit of claim 5, wherein the expandable structure comprises a proximal anchor component and a distal anchor component.

17. The anchoring component of claim 16, wherein the proximal anchor component and the distal anchor component are configured to interface with the tissue component.

18. A method of improving a valve competency comprising:

providing the anchoring conduit of claim 5 to an area proximate a heart valve, wherein the harbor is enabled to releasably connect a heart valve prosthesis;

deploying the anchoring conduit, the deployment of the anchoring conduit defining the open cavity; and

deploying a heart valve prosthesis in the open cavity of the anchoring conduit.

19. The method of improving a valve competency of claim 18, wherein deploying the heart valve prosthesis involves expanding the heart valve prosthesis within the open cavity of the anchoring conduit.

20. The method of improving a valve competency of claim 18, wherein the anchoring conduit provides a first releasably engaging component and the heart valve prosthesis provides a second releasably engaging component enabled to be securely coupled and uncoupled from the first releasably engaging component of the anchoring conduit.

21. The method of improving a valve competency of claim 20, wherein deploying the heart valve prosthesis involves securely coupling the second releasably engaging component of the heart valve prosthesis to the first releasably engaging component of the anchoring conduit.

22. The method of improving a valve competency of claim 21, further comprising:

removing the heart valve prosthesis from the anchoring conduit; and

deploying a second heart valve prosthesis in the open cavity of the anchoring conduit.

23. A method of improving a deficient heart valve comprising:

delivering the anchoring conduit of claim 5 to a heart valve;

delivering a temporary valve, in a condensed state, to a target site proximate the heart valve;

deploying the temporary valve at the target site proximate the heart valve; and

deploying the anchoring conduit in the heart valve, the deployment of the anchoring conduit disabling the heart valve; and

wherein the temporary valve operates to temporarily replace the function of the heart valve when the anchoring conduit is expanded.

24. The method of improving a deficient heart valve of claim 23, further comprising:

delivering the heart valve prosthesis to an area in the heart proximate the anchoring conduit; and

coupling the heart valve prosthesis to the harbor of the anchoring conduit.

25. The method of improving a deficient heart valve of claim 24, further comprising removing the temporary valve.

26. The method of improving a deficient heart valve of claim 25, further comprising:

delivering a temporary valve, in a condensed state, to a target site in an artery proximate the heart valve;

expanding the temporary valve at the target site in the artery proximate the heart valve;

decoupling the heart valve prosthesis from the harbor of the anchoring conduit;

delivering a second heart valve prosthesis to an area in the heart proximate the anchoring conduit; and

coupling the second heart valve prosthesis to the harbor of the anchoring conduit.

27. The method of improving a deficient heart valve of claim 26, further comprising removing the temporary valve.

28. The method of improving a deficient heart valve of claim 24, wherein the temporary valve and the heart valve prosthesis are endovascularly delivered.

29. The method of improving a deficient heart valve of claim 28, wherein the heart valve prosthesis can be delivered through a conduit in the temporary valve.

30. The method of improving a deficient heart valve of claim 23, wherein the heart valve is an aortic valve.

31. The method of improving a deficient heart valve of claim 23, wherein the heart valve is a pulmonic valve.

32. A cardiac prosthetic system comprising:

the anchoring conduit of claim 5;

a temporary valve; and

a heart valve prosthesis having a second releasably engaging component enabled to be securely coupled and uncoupled from the first releasably engaging component of the harbor.

33. The cardiac prosthetic system of claim 32, further comprising a second heart valve prosthesis, the second heart valve prosthesis having a third releasably engaging component enabled to be coupled and uncoupled from the first releasably engaging component of the harbor.

34. The cardiac prosthetic system of claim 32, wherein the anchoring conduit is enabled to be deployed in an aortic heart valve.

35. The cardiac prosthetic system of claim 32, wherein the anchoring conduit is enabled to be deployed in a pulmonic heart valve.

36. The cardiac prosthetic system of claim 32, wherein the anchoring conduit is enabled to be delivered through a blood vessel.

37. The cardiac prosthetic system of claim 32, wherein the temporary valve is enabled to temporarily perform the function of a heart valve.

38. The cardiac prosthetic system of claim 32, wherein the temporary valve and the heart valve prosthesis are endovascularly delivered.

39. The cardiac prosthetic system of claim 38, wherein the heart valve prosthesis can be delivered through a conduit in the temporary valve.

40. A cardiac device comprising:

a heart valve prosthesis having a releasably engaging component; and

the anchoring conduit of claim 5;

wherein the releasably engaging component is enabled to be connected to the harbor located within a heart.

41. The cardiac device of claim 40, wherein the releasably engaging component of the harbor is capable of being coupled to the releasably engaging component of the heart valve prosthesis.

42. The cardiac device of claim 40, wherein the heart valve prosthesis is enabled to be released from its connection to the harbor located within the heart.