Compounds and methods for treatment and prevention of diseases

• US 8,569,333 B2
• Filed: 05/27/2011
• Issued: 10/29/2013
• Est. Priority Date: 09/24/1998
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Mollison, Karl W., LeCaptain, Angela M., Burke, Sandra E., Cromack, Keith R., Tarcha, Peter J., Chen, Yen-Chih J., Toner, John L.
• Primary Examiner(s): Kifle, Bruck
• Application Number:
  US13/118,342
• Publication Number:
  US 20110230515A1
• Time in Patent Office: 886 Days
• Field of Search: 540/456, 514/291
• US Class Current: 514/291
• CPC Class Codes: A61L 2300/254 Enzymes, proenzymes
• CPC Class Codes: A61L 2300/40 characterised by a specific therapeutic activity or mode of action
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: C07D 498/14 : Ortho-condensed systems
• CPC Class Codes: C07D 498/18 : Bridged systems

Abstract

A prodrug compound of a rapamycin analog and methods for inhibiting, treating, and preventing mammalian diseases.

Claims

1. A prodrug according to formula:

2. A method for inhibiting or treating restenosis in a mammal in need of treatment comprising the step of administering the prodrug of claim 1 to the mammal.

3. A method for inhibiting or treating post-transplant-tissue transplant rejection in a mammal in need of treatment comprising the step of administering the prodrug of claim 1 to the mammal.

4. A method for inhibiting or treating fungal growth in a mammal in need of treatment comprising the step of administering the prodrug of claim 1 to the mammal.