Treating glaucoma

• US 8,580,789 B2
• Filed: 04/02/2008
• Issued: 11/12/2013
• Est. Priority Date: 04/02/2007
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation, Stephen Trokel
• Inventors: Krueger, Ronald R., Dupps, William J., Trokel, Stephen, Thornton, Ivey
• Primary Examiner(s): Huang, Gigi
• Application Number:
  US12/593,720
• Publication Number:
  US 20100189817A1
• Time in Patent Office: 2,050 Days
• Field of Search: 514/251, 514/705, 514/912, 514/913
• US Class Current: 514/251
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/11 Aldehydes
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics

Abstract

Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and treating the glaucoma in the individual. In yet another embodiment, the invention is directed to methods of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and treating the glaucomatous optic neuropathy in the individual. The method can further comprise administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal'"'"'s lamina cribrosa (LC).

Claims

1. A method of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of riboflavin and an ultraviolet A (UVA) light exposure wherein the light has a wavelength of about 365 nm to about 475 nm, to the individual'"'"'s peripapillary sclera, optic nerve, and lamina cribrosa, which results in crosslinking of collagen in the indiviudal'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and treating the glaucoma in the individual.

2. The method of claim 1 wherein the riboflavin concentration is from about 0. 05% to about 0,2% and the light has a wavelength of about 430 nm to about 475 nm.

3. A method of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of riboflavin and an ultraviolet A (UVA) light exposure wherein the light has a wavelength of about 365 nm to about 475 nm, to the individual'"'"'s peripapillary sclera, optic nerve, and lamina cribrosa, which results in crosslinking of collagen in the individual'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and treating the glaucomatous optic neuropathy in the individual.

4. The method of claim 3 wherein the riboflavin concentration is from about 0. 05% to about 0.2% and the light has a wavelength of about 430 nm to about 475 nm.

5. A method of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa complex against the biomechanical effects of increased intraocular pressure from glaucoma in an individual in need thereof, comprising contacting the individual'"'"'s peripapillary sclera, optic nerve, and lamina cribrosa with a therapeutically effective amount of riboflavin and an ultraviolet A (UVA) light exposure wherein the light has a wavelength of about 365 nm to about 475 nm, which results in the crosslinking of collagen in the individual'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa against the increased intraocular pressure from glaucoma in the individual.

6. The method of claim 5 wherein the riboflavin concentration is from about 0. 05% to about 0.2% and the light has at a wavelength of about 430 nm to about 475 nm.

7. A method of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa complex against the biomechanical effects of increased intraocular pressure from glaucoma in an individual in need thereof, comprising contacting the individual'"'"'s peripapillary sclera with a therapeutically effective amount of glutaraldehyde which results in the crosslinking of collagen in the individual'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa against the increased intraocular pressure from glaucoma in the individual.

8. A method of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of glutaraldehyde to the individual'"'"'s peripapillary sclera which results in crosslinking of collagen in the individual'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and treating the glaucoma in the individual.

9. A method of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of glutaraldehyde to the individual'"'"'s peripapillary sclera which results in crosslinking of collagen in the individual'"'"'s peripapillary sclera, thereby stiffening the individual'"'"'s peripapillary sclera and treating the glaucomatous optic neuropathy in the individual.