Reaction device controlled by magnetic control signal

• US 8,585,684 B2
• Filed: 11/09/2005
• Issued: 11/19/2013
• Est. Priority Date: 11/09/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hood, Leroy E., Ishikawa, Muriel Y., Jung, Edward K. Y., Langer, Robert, Tegreene, Clarence T., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): SCHMIDT, EMILY LOUISE
• Application Number:
  US11/271,145
• Publication Number:
  US 20070106267A1
• Time in Patent Office: 2,932 Days
• Field of Search: 604/20, 604 65- 67, 6048901-8921
• US Class Current: 604/891.1
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: B01J 19/0006 Controlling or regulating processes controlling or regulating in general G05
• CPC Class Codes: B01J 2219/00049 Controlling or regulating processes
• CPC Class Codes: C02F 1/008 Control or steering systems not provided for elsewhere in subclass C02F
• CPC Class Codes: C02F 1/02 by heating methods of steam generation F22B; preheating boiler feed-water or accumulating preheated boiler feed-water F22D
• CPC Class Codes: C02F 1/66 by neutralisation; pH adjustment for degassing C02F1/20; using ion-exchange C02F1/42; for flocculation or precipitation of suspended impurities C02F1/52; for removing dissolved compounds C02F1/58
• CPC Class Codes: C02F 2101/20 : Heavy metals or heavy metal compounds
• CPC Class Codes: C02F 2101/363 : PCB's; PCP's
• CPC Class Codes: C02F 2209/02 : Temperature
• CPC Class Codes: C12N 9/0004 : Oxidoreductases (1.)
• CPC Class Codes: C12N 9/0006 : acting on CH-OH groups as donors (1.1)
• CPC Class Codes: C12N 9/10 : Transferases (2.) ribonucleases C12N9/22
• CPC Class Codes: C12N 9/12 : transferring phosphorus containing groups, e.g. kinases (2.7)
• CPC Class Codes: C12N 9/14 : Hydrolases (3)
• CPC Class Codes: C12N 9/88 : Lyases (4.)
• CPC Class Codes: C12N 9/90 : Isomerases (5.)
• CPC Class Codes: C12N 9/93 : Ligases (6)
• CPC Class Codes: G08C 17/02 : using a radio link

Abstract

Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

Claims

1. A system comprising:

a body structure adapted for positioning in an environment;

a reaction region operably coupled to the body structure including a first material configured to influence a chemical reaction involving at least one material from the environment; and

a remotely activatable control element operably coupled to the body structure and responsive to a static or quasi-static magnetic field control signal or a static or quasi-static electric field control signal to modify one or more of the rate or kinetics of the chemical reaction on the reaction region, wherein the remotely activatable control element responds to the control signal by changing in at least one dimension, wherein additional portions of the reaction region are exposed responsive to the change in at least one dimension of the remotely activatable control element, and wherein exposure of additional portions of the reaction region exposes additional functional groups to produce at least a local change in osmolality, pH, surface energy, or surface charge.

2. The system of claim 1, wherein the reaction region is located in an interior portion of the body structure and is at least intermittently in fluid communication with the environment via at least one inlet or outlet.

3. The system of claim 2, further including a valve responsive to the change in at least one dimension of the remotely activatable control element to modify at least one of the flow of fluid into the reaction region or the flow of fluid out of the reaction region responsive to the change in at least one dimension of the remotely activatable control element.

4. The system of claim 1, wherein the reaction region is located on an exterior portion of the body structure in fluid communication with the environment.

5. The system of claim 1, wherein the remotely activatable control element includes a valve element or a structural element.

6. The system of claim 1, wherein the remotely activatable control element modifies one or more of the rate or kinetics of the chemical reaction by modifying the influence of the first material on the chemical reaction, or the rate of exposure of a reactant configured to participate in the chemical reaction to the first material.

7. The system of claim 1, wherein the remotely activatable control element includes at least one of a polymer, ceramic, dielectric, metal, shape memory material, bimetallic structure, hydrogel, ferrogel, ferroelectric, magnetically active material, or electrically active material.

8. The system of claim 1, wherein at least one of a surface area of the reaction region or a volume containing the reaction region within the interior portion of the body structure is increased responsive to the change in at least one dimension of the remotely activatable control element.

9. The system of claim 1, including at least one of an outlet through which a product of the chemical reaction is released into the environment or an inlet through which a second material configured to participate in the chemical reaction enters the reaction region.

10. The system of claim 1, wherein the first material is selected from a reactant that is modified by participation in the chemical reaction, a non-reactant material that modifies at least one condition at which the chemical reaction occurs, or a catalyst that facilitates the chemical reaction but is not significantly modified by the chemical reaction.

11. The system of claim 1, including a body structure adapted for positioning in the environment, wherein the environment is selected from a body of an organism, a body of water, a contained fluid volume, an industrial fluid volume, an agricultural fluid volume, a swimming pool, an aquarium, a drinking water supply, and a HVAC system cooling water supply.