Pirfenidone treatment for patients with atypical liver function

  • US 8,592,462 B2
  • Filed: 12/06/2011
  • Issued: 11/26/2013
  • Est. Priority Date: 11/10/2008
  • Status: Active Grant
First Claim
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1. A method of administering pirfenidone to treat a patient with idiopathic pulmonary fibrosis (IPF), said patient having exhibited an increase of about 2.5-fold to about 5-fold, compared to the upper limit of normal, in one or both of alanine transaminase and aspartate transaminase after a first pirfenidone administration, comprising providing to said patient a second administration of pirfenidone, comprising (a) administering to said patient pirfenidone at a dose of at least 1600 mg/day.

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