Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds

• US 8,597,264 B2
• Filed: 03/24/2011
• Issued: 12/03/2013
• Est. Priority Date: 03/24/2011
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Zimnitsky, Dmitry, Finkbiner, Jenny
• Primary Examiner(s): HAND, MELANIE JO
• Application Number:
  US13/071,387
• Publication Number:
  US 20120245540A1
• Time in Patent Office: 985 Days
• Field of Search: 604/304, 604/313, 604/319, 602/46, 602/48, 602/50, 602/56, 424/443, 424/447, 424/449, 424/473, 424/476, 424/485, 424/486, 424/492, 424/498, 424/502, 424/520
• US Class Current: 604/313
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 33/18 Iodine; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 38/17 from animals; from humans enzyme inhibitors A61K38/005
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/32 Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2300/21 Acids
• CPC Class Codes: A61L 2300/254 Enzymes, proenzymes
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61M 1/916 specially adapted for deep wounds
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a homogenous mixture, such as a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension or applied on a carrier material, such as a bandage, gauze, foam, sponge, hydrogel, hydrocolloid, hydrofiber, occlusive dressing, adhesive composition or scaffold. Methods for producing such a topical composition and carrier material with the topical composition applied thereto are also disclosed.

Claims

1. A system for treating a wound at a tissue site, comprising:

a pressure source to supply reduced pressure;

wound dressing in fluid communication with said pressure source to distribute reduced pressure to the wound, said wound dressing having a first portion contacting the wound and a second portion;

a lipoic acid derivative and a sacrificial proteolytic enzyme applied to the second portion of said wound dressing; and

a drape adapted to cover said wound dressing and the wound to provide a sealed space for applying the reduced pressure to the wound.

2. The system of claim 1, wherein the first portion of said wound dressing is a scaffold.

3. The system of claim 2, wherein the lipoic acid derivative and the sacrificial proteolytic enzyme are applied to the scaffold.

4. The system of claim 1, wherein the wound dressing further comprises a scaffold.

5. The system of claim 4, wherein the scaffold is comprised of polyurethane or collagen.

6. The system of claim 4, wherein the lipoic acid derivative and the sacrificial proteolytic enzyme are applied to the scaffold.

7. The system of claim 1, wherein the lipoic acid derivative and the sacrificial proteolytic enzyme are combine in a homogenous mixture.

8. The system of claim 7, wherein the homogenous mixture is applied to both the first portion and the second portion of said wound dressing.

9. The system of claim 7, wherein the homogenous mixture is applied to the surface of said wound dressing.

10. The system of claim 7, wherein the homogenous mixture is applied to internal portions of said wound dressing.

11. The system of claim 1, wherein the sacrificial proteolytic enzyme substrate comprises gelatin.