Usability features for integrated insulin delivery system

• US 8,597,274 B2
• Filed: 05/21/2010
• Issued: 12/03/2013
• Est. Priority Date: 05/22/2009
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Sloan, Mark, Taub, Marc B., Hayter, Gary A., Harper, Wesley Scott, Budiman, Erwin S., Wei, Charles
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): GILBERT, ANDREW M
• Application Number:
  US12/785,144
• Publication Number:
  US 20100295686A1
• Time in Patent Office: 1,292 Days
• Field of Search: 6048901-8911, 604 65- 67, 604503-504
• US Class Current: 604/504
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61M 2005/14296 Pharmacokinetic models
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G08B 21/0453 worn on the body to detect health condition by physiological monitoring, e.g. electrocardiogram, temperature, breathing detecting, measuring or recording for diagnostic purposes A61B5/00
• CPC Class Codes: G08B 21/182 Level alarms, e.g. alarms responsive to variables exceeding a threshold
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

Various systems and methods for improving the usability of continuous glucose monitors and drug delivery pumps are described.

Claims

1. A method of determining an insulin delivery rate when a closed loop insulin delivery system delivering insulin to a user at a pre-programmed basal delivery rate terminates unexpectedly, comprising:

a) providing a glucose level and predicting a future glucose level in order to determine an appropriate insulin bolus value for a latest control command, and assuming that this command is immediately followed by open loop control where the pre-programmed basal delivery rate will be in effect thereafter;

b) analyzing the predicted future glucose level using the insulin bolus value of the latest control command plus a future basal rate to determine if the predicted future glucose level is acceptable, and if so, waiting for a selected period of time and repeating step a);

c) if the predicted future glucose level of step b) is not acceptable, computing an alternate temporary basal delivery amount that is lower than the previously assumed future basal rate, and, if the predicted future glucose level is acceptable, providing a temporary basal command at a computed basal rate and duration, waiting for a selected period of time and repeating step a);

d) if the predicted future glucose level in step c) is unacceptable, decreasing the alternate temporary basal delivery amount by an amount determined by a minimum bolus resolution provided by the insulin delivery system, projecting the predicted future glucose level, and, if the predicted future glucose level is acceptable, providing a temporary basal command including a rate and duration and then waiting for a selected period of time and repeating step a); and

e) if the predicted future glucose level in step d) is unacceptable, reducing the alternate temporary basal rate delivery amount by a selected amount, projecting the predicted future glucose level, and if the predicted future glucose level is acceptable, providing a temporary basal command including a rate and duration and then wait for a selected period of time and repeating step a); and

f) if the predicted future glucose level in step e) is unacceptable, repeating steps d) and e) until an acceptable predicted glucose profile achieved.

2. The method of claim 1, further comprising alerting the user to take action to counter an effect of excessive insulin if the acceptable predicted glucose profile cannot be obtained in step f).

3. A method of determining a latest insulin delivery amount and a temporary insulin delivery rate to be delivered when a closed loop insulin delivery system terminates unexpectedly, comprising:

a) providing a glucose level and predicting a future glucose level in order to determine an appropriate insulin amount for a latest control command, and assuming that this command is immediately followed by open loop control where a pre-programmed temporary basal rate will be in effect thereafter;

b) analyzing the predicted future glucose level using the insulin amount of the latest control command plus a future temporary basal rate to determine if the predicted future glucose level is acceptable, and if so, waiting for a selected period of time and repeating step a);

c) if the predicted future glucose level of step b) is not acceptable, computing an alternate temporary basal delivery amount that is lower than the previously assumed future temporary basal rate, and if the predicted future glucose level is acceptable, providing a temporary basal command at a computed basal rate and duration, and waiting for a selected period of time and repeating step a);

d) if the predicted future glucose level in step c) is unacceptable, decreasing the alternate temporary basal delivery amount, projecting the predicted future glucose level, and, if the predicted future glucose level is acceptable, providing a temporary basal command including a rate and duration and then waiting for a selected period of time and repeating step a);

e) if the predicted future glucose level in step d) is unacceptable, reducing the temporary basal command by a predetermined minimum insulin delivery resolution and waiting a selected period of time and repeating step a); and

f) if the predicted future glucose level in step e) is unacceptable, repeating steps d) and e) until an acceptable predicted glucose profile is achieved.

4. The method of claim 3, further comprising alerting the user to take action to counter an effect of excessive insulin if the acceptable predicted glucose profile cannot be obtained in step f).