Textile graft for in situ fenestration

• US 8,597,342 B2
• Filed: 08/21/2008
• Issued: 12/03/2013
• Est. Priority Date: 08/24/2007
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: McKinsey, James F., Kuppurathanam, Shyam S V, Waninger, Matthew S.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): SCHALL, MATTHEW WAYNE
• Application Number:
  US12/195,762
• Publication Number:
  US 20090157164A1
• Time in Patent Office: 1,930 Days
• Field of Search: 623/1.15, 623/1.35, 623/1.32, 623/1.34, 623/1.49, 623/1.5, 623/1.51, 623/1.53, 623/1.54, 623/1.13
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2002/061 provided with means for allowing access to secondary lumens
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0017 differing in yarn density

Abstract

The disclosure relates to an implantable woven graft for bridging a defect in a main vessel near one or more branch vessels. The graft includes a region of reduced yarn density. Reduced yarn density regions are alignable with at least one of the one or more branch vessels, and are suitable for in situ fenestration, for example by perforation. The disclosed examples are particularly suited for bridging abdominal aortic aneurysms.

Claims

1. An implantable graft comprising:

a main graft body forming a lumen with a proximal end and a distal end;

where at least a portion of the lumen is defined by a woven fabric comprising yarns aligned in a first direction interwoven with yarns aligned in a second direction;

where the woven fabric further comprises a main portion and at least one reduced yarn density region disposed between the proximal and distal end;

where, although at least some yarns traverse the reduced yarn density region, the reduced yarn density region is defined by having a lower yarn density than the main portion; and

where both the main portion and the reduced yarn density region are substantially impermeable to fluid flow.

2. The graft of claim 1, where the reduced yarn density region has between about 10% and about 90% fewer yarns aligned in the first direction than in the main portion.

3. The graft of claim 1, where the reduced yarn density region has between about 65% and about 85% fewer yarns aligned in the first direction than the main portion.

4. The graft of claim 1, where the at least one reduced yarn region comprises a first weave density about the circumference of the at least one reduced yarn density region and a second weave density about the center of the at least one reduced yarn density region, where the first weave density is more than the second weave density.

5. The graft of claim 1, where the yarns comprise a polymer selected from the group consisting of polyester, polypropylene, polyethylene, polyurethane, and polytetrafluoroethylene, and combinations thereof.

6. The graft of claim 4, where the polymer comprises polyester.

7. The graft of claim 1, where the reduced yarn density region is round, obround, polygonal, rectangular, square, or freeform, or combinations thereof.

8. The graft of claim 1, where the reduced yarn density region comprises a circumferential width which is less than the circumference of the lumen.

9. The graft of claim 1, where the yarns aligned in the first direction comprise warp yarns, and the yarns aligned in the second direction comprise weft yarns.

10. The graft of claim 9, where the main portion comprises between about 50 and about 300 weft yarns per inch and between about 50 and about 300 warp yarns per inch and where the reduced yarn density region comprises between about 10 and about 200 weft yarns per inch and between about 10 and about 200 warp yarns per inch.

11. The graft of claim 9, where the main portion comprises 150 weft yarns per inch and 250 warp yarns per inch and where the at least one reduced yarn density region comprises between about 20 and about 50 weft yarns per inch.

12. The graft of claim 1, further comprising at least one radiopaque element attached to the main graft body.

13. The graft of claim 12, where the at least one radiopaque element is located adjacent the reduced yarn density region.

14. An implantable prosthesis for treatment of a main vessel defect near one or more branch vessels, said prosthesis comprising:

a graft comprising yarns aligned in a first direction interwoven with yarns aligned in a second direction, the woven yarns defining a lumen with a proximal end and a distal end, a main portion and at least one passage disposed between the proximal and distal end;

where, although at least some yarns traverse the passage, the passage is defined by having a lower yarn density than the main portion; and

where both the main portion and the passage are substantially impermeable to fluid flow.

15. The prosthesis of claim 14, further comprising at least two stents attached to the graft, one of which is attached between the distal end and the passage, the other of which is attached between the proximal end and the passage.

16. The prosthesis of claim 14, further comprising attachment mechanisms for securing the prosthesis within the main vessel selected from the group consisting of anchoring members, sutures, staples, searing, bonding, and bioadhesives, and combinations thereof.

17. The prosthesis of claim 14, further comprising a therapeutic agent adapted to be released from the prosthesis after implantation.

18. The prosthesis of claim 14, further comprising at least one radiopaque element for orienting the prosthesis within said main vessel.

19. The prosthesis of claim 15, further comprising a stent attached to the lumen distal end and stent attached to the lumen proximal end.

20. A method of bridging a defect in a main vessel near at least one branch vessel comprising:

providing a prosthesis comprising at least one stent and an implantable textile graft comprising yarns aligned in a first direction interwoven with yarns aligned in a second direction, said woven yarns defining a lumen with a main portion and at least one reduced yarn density region, wherein the reduced yarn density region has a yarn density lower than the main portion, where both the main portion and the reduced yarn density region are substantially impermeable to blood flow;

deploying the prosthesis into the main vessel of a patient in need thereof such that the reduced yarn density region is aligned with the at least one branch vessel;

perforating the at least one reduced yarn density region with a guidewire to define a passageway permitting blood flow from the main vessel to the at least one branch vessel.