Uniform films for rapid dissolve dosage form incorporating taste-masking compositions

CAFC
  • US 8,603,514 B2
  • Filed: 07/10/2007
  • Issued: 12/10/2013
  • Est. Priority Date: 04/11/2002
  • Status: Active Grant
First Claim
Patent Images

1. A drug delivery composition comprising:

  • (i) a cast film comprising a flowable water-soluble or water swellable film-forming matrix comprising one or more substantially water soluble or water swellable polymers; and

    a desired amount of at least one active;

    wherein said matrix has a viscosity sufficient to aid in substantially maintaining non-self-aggregating uniformity of the active in the matrix;

    (ii) a particulate active substantially uniformly stationed in the matrix; and

    (iii) a taste-masking agent coated or intimately associated with said particulate to provide taste-masking of the active;

    wherein the combined particulate and taste-masking agent have a particle size of 200 microns or less and said flowable water-soluble or water swellable film-forming matrix is capable of being dried without loss of substantial uniformity in the stationing of said particulate active therein; and

    wherein the uniformity subsequent to casting and drying of the matrix is measured by substantially equally sized individual unit doses which do not vary by more than 10% of said desired amount of said at least one active.

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