Pharmaceutical compositions comprising colloidal silicon dioxide

  • US 8,617,598 B2
  • Filed: 06/05/2012
  • Issued: 12/31/2013
  • Est. Priority Date: 09/28/2001
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition in the form of a dispersible tablet to be dispersed in an ingestible liquid before administration to a patient, comprising a solid dispersion of 40-O-(2-hydroxy)ethyl-rapamycin, a disintegrant comprising cross-linked polyvinylpyrrolidone and colloidal silicon dioxide, wherein the composition comprises 1 to 5% colloidal silicon dioxide by weight and 10 to 30% of cross-linked polyvinylpyrrolidone by weight, and wherein the tablet has a disintegration time of 3 minutes or less and a hardness of 35 to 80N.

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