Polymer-factor VIII conjugate compositions

  • US 8,618,259 B2
  • Filed: 03/27/2012
  • Issued: 12/31/2013
  • Est. Priority Date: 02/26/2003
  • Status: Active Grant
First Claim
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1. A composition that is at least 85% free from albumin, the composition comprising a conjugate comprising a water-soluble polymer covalently attached to a Factor VIII polypeptide via a thiol group of a cysteine residue that has been added to or substituted in the Factor VIII polypeptide, wherein the water-soluble polymer is selected from the group consisting of poly(alkylene glycol), poly(oxyethylated polyol), poly(olefinic alcohol), poly(vinylpyrrolidone), poly(hydroxyalkylmethacrylamide), poly(hydroxyalkylmethacrylate), poly(saccharide), poly(α

  • -hydroxy acid), poly(vinyl alcohol), polyphosphazene, polyoxazoline, poly(N-acryloylmorpholine), and combinations thereof.

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