Injection device with simplified stopper retention

• US 8,622,956 B2
• Filed: 02/25/2009
• Issued: 01/07/2014
• Est. Priority Date: 08/30/2006
• Status: Expired due to Fees

• Current Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Original Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Inventors: Heutschi, Ivan
• Primary Examiner(s): Schmidt, Emily
• Assistant Examiner(s): Thomas, Jr., Bradley G
• Application Number:
  US12/392,425
• Publication Number:
  US 20090247957A1
• Time in Patent Office: 1,777 Days
• Field of Search: 604218-222, 604/232, 604/233, 604/82, 604/85, 604 89- 92
• US Class Current: 604/89
• CPC Class Codes: A61M 5/31515 Connection of piston with piston rod

Abstract

An injection device including a volume for accommodating a product for administration, a piston for acting upon the product within the volume, and a stopper which can be arranged between an end of the piston facing the product and the product within the volume, wherein the piston includes a piston head configured to be sealed in a gas-tight manner, the piston head being separate from the stopper such that a negative pressure or vacuum region can be developed between the piston head and the stopper.

Claims

1. An injection device comprising:

a first volume for accommodating a product for administration, a piston for acting upon the product within the first volume, and a stopper disposed between an end of the piston facing the product and the product within the first volume, a second volume being defined between the stopper and the end of the piston facing the product, wherein the piston comprises a piston head configured such that when the piston is advanced in an administration direction, fluid outflow is permitted from the second volume in a direction generally opposite the administration direction and wherein the piston head is separate from the stopper such that a negative pressure or vacuum region can be developed in the second volume.

2. The injection device as claimed in claim 1, wherein the piston head further comprises a sealing lip extending about the full circumference of the piston head and which provides a substantially gas-tight seal with respect to a wall of the first and/or second volumes.

3. The injection device as claimed in claim 2, wherein the sealing lip comprises a predetermined leakage arrangement in the administration direction.

4. The injection device as claimed in claim 1, the injection device further comprising a piston rod, wherein the piston rod comprises a hollow conduit that can be opened and/or closed.

5. The injection device as claimed claim 2, wherein the sealing lip is designed to be invertible or bendable.

6. The injection device as claimed in claim 5, wherein the piston further comprises a piston rod configured such that when inserted into the first volume, air or gas between the stopper and the piston head can escape.

7. The injection device as claimed in claim 1, wherein the piston head comprises a sealing mechanism.

8. The injection device as claimed in claim 4, wherein at least one of the piston head and piston rod comprise at least one valve.

9. The injection device as claimed in claim 8, wherein the valve is a one-way valve.

10. The injection device as claimed in claim 8, wherein the valve is a two-way valve.

11. The injection device as claimed in claim 8, wherein at least one of the piston head and the piston rod comprise a first valve and a second valve, the first valve having a lower trigger pressure than the second valve, wherein one of first and second valves is active in a first direction and the other is active in a second direction generally opposite the first direction.

12. The injection device as claimed in claim 8, wherein the at least one valve comprises a membrane which is freely movable in an air or gas outlet direction, and wherein the membrane is supported in an air inlet direction and is configured to sealingly bear on a membrane support such that a negative pressure or vacuum region can be developed between the stopper and the piston head.

13. The injection device as claimed in claim 1, wherein the stopper has at least one radial indentation.

14. The injection device as claimed in claim 13, wherein an end of the stopper facing toward the piston head comprises at least one cavity formed in the axial direction of the stopper.

15. An injection device comprising:

a first volume for accommodating a product for administration,

a piston for acting upon the product within the first volume in an administration direction, the piston comprising a piston head on a distal end thereof, and

a stopper disposed between the piston head and the product within the first volume,

wherein a second volume is defined between the piston head and a proximal end of the stopper, and

wherein the piston head comprises a outflow permitting structure that is configured such that when the piston head is advanced in the administration direction fluid outflow is permitted from the second volume in a direction generally opposite the administration direction to achieve a negative pressure region in the second volume, thereby reducing movements of the stopper in the administration direction independent of movement of the piston.

16. The injection device as claimed in claim 15, wherein the piston head and the first and second volumes are configured such that the negative pressure region is maintained substantially throughout movement of the stopper from an initial position to a final position in which the product has been substantially emptied from the first volume.

17. The injection device as claimed in claim 15, wherein the outflow permitting structure comprises a sealing lip.

18. The injection device as claimed in claim 15, wherein the outflow permitting structure comprises a valve.