Treatment of pluripotent cells
First Claim
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1. A method to expand and differentiate human pluripotent cells, comprising the steps of:
- a. Culturing human pluripotent cells, andb. Treating the human pluripotent cells with an inhibitor of glycogen synthase kinase 3β
(GSK-3B)enzyme activity consisting of 3-[1-(2- Hydroxyethyl)-1H-indol-3-yl]-4-(1-pyridin-3-yl-1H-indol-3-yl)-1H-pyrrole-2,5-dione.
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Abstract
The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.
118 Citations
11 Claims
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1. A method to expand and differentiate human pluripotent cells, comprising the steps of:
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a. Culturing human pluripotent cells, and b. Treating the human pluripotent cells with an inhibitor of glycogen synthase kinase 3β
(GSK-3B)enzyme activity consisting of 3-[1-(2- Hydroxyethyl)-1H-indol-3-yl]-4-(1-pyridin-3-yl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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