Unifying mechanism and methods to prevent cancer and neurodegenerative diseases

• US 8,629,174 B2
• Filed: 07/31/2009
• Issued: 01/14/2014
• Est. Priority Date: 03/14/2002
• Status: Active Grant

• Current Assignee: Prevention, LLC
• Original Assignee: Prevention, LLC
• Inventors: Cavalieri, Ercole L., Rogan, Eleanor G.
• Primary Examiner(s): HUI, SAN MING R
• Application Number:
  US12/533,883
• Publication Number:
  US 20090312391A1
• Time in Patent Office: 1,628 Days
• Field of Search: 514/418, 514/557, 514/734
• US Class Current: 514/418
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/381 having five-membered rings
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/4045 Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C12Q 1/686 Polymerase chain reaction [PCR]
• CPC Class Codes: Y10T 436/143333 Saccharide [e.g., DNA, etc.]

Abstract

The present invention relates to methods for preventing the development of cancer or neurodegenerative diseases by administering N-Acetylcysteine (NAC), melatonin, or a combination thereof. The present invention also relates to methods for diagnosing cancer and/or neurdegenerative disease by detecting or determining the amount of dopamine metabolites, 4-CE, 2-CE, methylation of CE or CE-Q conjugates.

Claims

1. A method for inhibiting depurinating DNA adduct formation in cells of a mammal comprising administering to the mammal an effective amount of N-acetylcysteine or a pharmaceutically acceptable salt thereof and resveratrol or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 wherein the mammal has a cancer selected from the group consisting of thymoma, lymphoma, sarcoma, lung cancer, liver cancer, brain cancer, non Hodgkin'"'"'s lymphoma, Hodgkins lymphoma, leukemias, uterine cancer, cervical cancer, bladder cancer, rectal cancer, kidney cancer, colon cancer, and adenocarcinomas such as breast cancer, prostate cancer, ovarian cancer, and pancreatic cancer.

4. The method of claim 1 further comprising administering an effective amount of a melatonin or a pharmaceutically acceptable salt thereof.

5. The method of claim 1 further comprising administering an effective amount of resveratrol.

6. The method of claim 1 further comprising administering and effective amount of lipoic acid.

2. A method for inhibiting depurinating DNA adduct formation in breast cells in a mammal comprising administering to the mammal an effective amount of a combination of N-acetylcysteine, melatonin, resveratrol and lipoic acid or pharmaceutically acceptable salts thereof.