Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis

  • US 8,637,451 B2
  • Filed: 12/29/2011
  • Issued: 01/28/2014
  • Est. Priority Date: 03/29/2001
  • Status: Active Grant
First Claim
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1. A method for stimulating water transport in the gastrointestinal tract in a patient comprising administering to said patient a guanylate cyclase receptor agonist peptide consisting of SEQ ID NO:

  • 20, wherein said peptide is administered in an amount sufficient to induce cGMP production in a gastrointestinal epithelial cell and wherein said peptide is (4,12;

    7,15) bicycle.

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