Pirfenidone therapy and inducers of cytochrome P450

  • US 8,648,098 B2
  • Filed: 12/15/2011
  • Issued: 02/11/2014
  • Est. Priority Date: 12/04/2009
  • Status: Active Grant
First Claim
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1. A method of increasing the effectiveness of pirfenidone therapy by avoiding decreased exposure to pirfenidone, in a patient in need of pirfenidone therapy who is a smoker, comprising discontinuing smoking to decrease levels of cytochrome P450 1A2 (CYP1A2) induction and then administering a therapeutically effective amount of pirfenidone.

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