Extended-release topiramate capsules

  • US 8,652,527 B1
  • Filed: 03/19/2013
  • Issued: 02/18/2014
  • Est. Priority Date: 03/13/2013
  • Status: Active Grant
First Claim
Patent Images

1. An extended-release topiramate capsule comprising:

  • a capsule shell comprising a single population of coated particles;

    wherein each coated particle comprises a core and a coating thereon;

    wherein each particle core comprises a homogeneous mixture throughout its core,the mixture comprising;

    40 wt-% to 50 wt-% of topiramate, based on the total weight of an uncoated particle core;

    45 wt-% to 55 wt-% of one or more filler(s), based on the total weight of an uncoated particle core; and

    3 wt-% to 7 wt-% of one or more binder(s), based on the total weight of an uncoated particle core;

    wherein the coating comprises;

    55 wt-% to 65 wt-% of one or more release control agent(s), based on the total weight of the coating;

    20 wt-% to 25 wt-% of one or more pore former(s), based on the total weight of the coating; and

    10 wt-% to 20 wt-% of one or more plasticizer(s), based on the total weight of the coating;

    wherein the particles are coated in an amount sufficient to provide a weight gain of 8% to 14%.

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