Analyte sensors comprising blended membrane compositions and methods for making and using them
First Claim
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1. An amperometric analyte sensor apparatus comprising:
- a base layer comprising a working electrode;
an analyte sensing layer coating the working electrode; and
an analyte modulating layer coating the analyte sensing layer, wherein;
the analyte modulating layer comprises a blended mixture of a linear polyurethane/polyurea polymer and a branched acrylate polymer;
the linear polyurethane/polyurea polymer exhibits a permeability to glucose that decreases by between 1% and 8% per degree centigrade as temperature is increased from 22 to 40 degrees centigrade;
the branched acrylate polymer exhibits a permeability to glucose that increases by between 1% and 8% per degree centigrade as temperature is increased from 22 to 40 degrees centigrade;
the linear polyurethane/polyurea polymer and the branched acrylate polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %; and
the analyte modulating layer comprises a blend of;
(1) a polyurethane/polyurea polymer formed from a mixture comprising;
(a) a diisocyanate;
(b) a hydrophilic polymer comprising a hydrophilic diol or hydrophilic diamine; and
(c) a siloxane having an amino, hydroxyl or carboxylic acid functional group at a terminus; and
(2) a branched acrylate polymer formed from a mixture comprising;
(a) a butyl, propyl, ethyl or methyl-acrylate;
(b) an amino-acrylate;
(c) a siloxane-acrylate; and
(d) a poly(ethylene oxide)-acrylate.
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Abstract
Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
119 Citations
16 Claims
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1. An amperometric analyte sensor apparatus comprising:
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a base layer comprising a working electrode; an analyte sensing layer coating the working electrode; and an analyte modulating layer coating the analyte sensing layer, wherein; the analyte modulating layer comprises a blended mixture of a linear polyurethane/polyurea polymer and a branched acrylate polymer; the linear polyurethane/polyurea polymer exhibits a permeability to glucose that decreases by between 1% and 8% per degree centigrade as temperature is increased from 22 to 40 degrees centigrade; the branched acrylate polymer exhibits a permeability to glucose that increases by between 1% and 8% per degree centigrade as temperature is increased from 22 to 40 degrees centigrade; the linear polyurethane/polyurea polymer and the branched acrylate polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %; andthe analyte modulating layer comprises a blend of; (1) a polyurethane/polyurea polymer formed from a mixture comprising; (a) a diisocyanate; (b) a hydrophilic polymer comprising a hydrophilic diol or hydrophilic diamine; and (c) a siloxane having an amino, hydroxyl or carboxylic acid functional group at a terminus; and (2) a branched acrylate polymer formed from a mixture comprising; (a) a butyl, propyl, ethyl or methyl-acrylate; (b) an amino-acrylate; (c) a siloxane-acrylate; and (d) a poly(ethylene oxide)-acrylate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of making an analyte sensor apparatus for implantation within a mammal comprising the steps of:
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providing a base layer; forming a working electrode on the base layer; forming an analyte sensing layer on the conductive layer, wherein the analyte sensing layer includes an oxidoreductase; forming an analyte modulating layer on the analyte sensing layer, wherein; the analyte modulating layer comprises a blended mixture of; (1) a first polymer formed from a mixture comprising; (a) a diisocyanate; (b) at least one hydrophilic diol or hydrophilic diamine; and (c) a siloxane; and (2) a second polymer formed from a mixture comprising; (a) a 2-(dimethylamino) ethyl methacrylate; (b) a methyl methacrylate; (c) a polydimethyl siloxane monomethacryloxypropyl; and (d) a poly(ethylene oxide) methyl ether methacrylate; and the first polymer and the second polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %; andforming a cover layer on the analyte modulating layer. - View Dependent Claims (13, 14, 15)
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16. An amperometric analyte sensor apparatus comprising:
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a base layer comprising a working electrode; an analyte sensing layer coating the working electrode; and an analyte modulating layer coating the analyte sensing layer, wherein the analyte modulating layer comprises a blend of; (1) a polyurethane/polyurea polymer formed from a mixture comprising; (a) a diisocyanate; (b) a hydrophilic polymer comprising a hydrophilic diol or hydrophilic diamine; and (c) a siloxane having an amino, hydroxyl or carboxylic acid functional group at a terminus; and (2) a branched acrylate polymer formed from a mixture comprising; (a) a butyl, propyl, ethyl or methyl-acrylate; (b) an amino-acrylate; (c) a siloxane-acrylate; and (d) a poly(ethylene oxide)-acrylate; and the polyurethane/polyurea polymer and the branched acrylate polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %.
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Specification