Sustained-release formulations of topiramate

  • US 8,663,683 B2
  • Filed: 08/27/2012
  • Issued: 03/04/2014
  • Est. Priority Date: 11/17/2006
  • Status: Active Grant
First Claim
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1. A sustained release formulation of topiramate for oral administration to a mammalian subject comprising topiramate as an active ingredient that is released in a continuous manner from the formulation along a pre-determined release profile, wherein the formulation comprises:

  • an extended release (XR) component comprising at least one population of beads, wherein greater than or equal to 80% of the topiramate contained therein is released in vitro in less than or equal to about 4 hours, and(ii) an immediate release (IR) component, wherein 80% of the topiramate contained therein is released in vitro in not more than 1 hour,wherein each bead population of the XR component is coated with its own release controlling coating and characterized by its own rate of release.

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