Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic

  • US 8,668,929 B2
  • Filed: 06/21/2012
  • Issued: 03/11/2014
  • Est. Priority Date: 03/11/2008
  • Status: Active Grant
First Claim
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1. A method for treating pain, comprising:

  • administering at least twice daily, a dosage form comprising an extended release polymer matrix comprising a dose of acetaminophen and a dose of an opioid, wherein the extended release matrix is comprised of a swellable polymer and imbibes fluid after administration to swell to a size sufficient to promote gastric retention of the matrix, wherein the swellable polymer is selected from the group consisting of a polyalkylene oxide, a cellulosic polymer, a poly(acrylamide), a poly(N-vinyl lactam), and a polyvinylamine, and wherein within about 1 hour in an in vitro disintegration test the dosage form releases more than about 50% of the dose of acetaminophen, and wherein by about 6 hours in an in vitro disintegration test, the percent of opioid released from the dosage form is greater than the percent of acetaminophen released from the dosage form, and wherein the in vitro disintegration test is at 37°

    C. in 0.1N HCl.

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