Methods and moulds for use in fabricating side-ported microneedles
First Claim
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1. A method of manufacturing a microneedle mould for use in fabricating microneedles, comprising:
- providing a microneedle mould base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mould base;
forming side-port forming holes in the microneedle mould base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mould base at side-port forming positions of the recesses; and
providing a seed layer on the first surface of the microneedle mould base and in the recesses,wherein forming the side-port forming holes comprises;
providing the side surfaces of the recesses with discontinuities at the side-port forming positions of the recesses; and
depositing the seed layer after providing the side-port forming discontinuities, with the seed layer failing to deposit substantially on the side-port forming discontinuities.
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Abstract
A microneedle mold and a method of manufacturing a microneedle mold are provided for use in fabricating microneedles. The method includes providing a microneedle mold base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mold base; and forming side-port forming holes in the microneedle mold base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mold base at side-port forming positions of the recesses.
42 Citations
33 Claims
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1. A method of manufacturing a microneedle mould for use in fabricating microneedles, comprising:
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providing a microneedle mould base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mould base; forming side-port forming holes in the microneedle mould base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mould base at side-port forming positions of the recesses; and providing a seed layer on the first surface of the microneedle mould base and in the recesses, wherein forming the side-port forming holes comprises; providing the side surfaces of the recesses with discontinuities at the side-port forming positions of the recesses; and depositing the seed layer after providing the side-port forming discontinuities, with the seed layer failing to deposit substantially on the side-port forming discontinuities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A microneedle mould comprising a microneedle mould base with a plurality of recesses extending from a first surface thereof and a plurality of side-port forming holes in the microneedle mould base, the side-port forming holes extending in side surfaces of the recesses within the microneedle mould base at side-port forming positions of the recesses,
wherein the side surfaces of the recesses are provided with discontinuities at the side-port forming positions of the recesses, and a seed layer is deposited on the first surface of the microneedle mould base and in the recesses, with the seeding layer failing to deposit substantially on the side-port forming discontinuities.
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27. A method of fabricating microneedles, comprising:
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providing a microneedle mould fabricated according to a method of manufacturing a microneedle mould for use in fabricating microneedles, the method of manufacturing a microneedle mould comprising; providing a microneedle mould base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mould base; and forming side-port forming holes in the microneedle mould base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mould base at side-port forming positions of the recesses; forming a microneedle layer onto a first surface of the microneedle mould and within the recesses of the microneedle mould, with gaps in the layers on the side-port forming holes; and removing the microneedle layer from the microneedle mould, the portions of the microneedle layer corresponding to the side-port forming holes comprising microneedle side-ports. - View Dependent Claims (28, 29, 30, 31, 32, 33)
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Specification