Methods of treating, reducing the incidence of, and/or preventing ischemic events

  • US 8,680,052 B1
  • Filed: 05/29/2013
  • Issued: 03/25/2014
  • Est. Priority Date: 03/09/2013
  • Status: Active Grant
First Claim
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1. A method of transitioning a patient from administration of cangrelor during percutaneous coronary intervention (PCI) to administration of ticagrelor for chronic treatment, the method comprising:

  • (1) administering intravenously a 30 μ

    g/kg bolus of cangrelor before the start of PCI;

    (2) administering intravenously a 4 μ

    g/kg/min continuous infusion of cangrelor after administration of the bolus;

    (3) continuing the administration of the continuous infusion for the longer of (a) at least two hours, or (b) the duration of PCI; and

    (4) administering an oral dose of ticagrelor either (a) during administration of the continuous infusion, or (b) after discontinuation of the administration of the continuous infusion, wherein the oral dose comprises a 180 mg loading dose of ticagrelor.

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