Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
First Claim
1. A method for modulating an activity of brown adipose tissue in a vertebrate subject comprising:
- inducing non-shivering thermogenesis in brown adipose tissue by applying cooling to a pulmonary vein and to one or more brown adipose tissues of the vertebrate subject with an implantable cooling system having at least a first portion including one or more cooling elements and a second portion including one or more cooling elements, the first portion at least partially implantable proximate a pulmonary vein and the second portion at least partially implantable proximate one or more brown adipose tissues;
wherein inducing non-shivering thermogenesis in the brown adipose tissue includesactivating at least the first portion implantable proximate the pulmonary vein so as to induce activation of thermoreceptors associated with the pulmonary vein, andactivating the second portion implantable proximate the one or more brown adipose tissues so as to induce non-shivering thermogenesis of the brown adipose tissue.
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Accused Products
Abstract
Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.
166 Citations
43 Claims
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1. A method for modulating an activity of brown adipose tissue in a vertebrate subject comprising:
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inducing non-shivering thermogenesis in brown adipose tissue by applying cooling to a pulmonary vein and to one or more brown adipose tissues of the vertebrate subject with an implantable cooling system having at least a first portion including one or more cooling elements and a second portion including one or more cooling elements, the first portion at least partially implantable proximate a pulmonary vein and the second portion at least partially implantable proximate one or more brown adipose tissues; wherein inducing non-shivering thermogenesis in the brown adipose tissue includes activating at least the first portion implantable proximate the pulmonary vein so as to induce activation of thermoreceptors associated with the pulmonary vein, and activating the second portion implantable proximate the one or more brown adipose tissues so as to induce non-shivering thermogenesis of the brown adipose tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for inducing weight loss in a vertebrate subject comprising:
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detecting via one or more sensor a glucose level of the vertebrate subject; and inducing non-shivering thermogenesis in brown adipose tissue by applying cooling to one or more brown adipose tissues and to a pulmonary vein of the vertebrate subject with an implantable cooling system having at least a first portion including one or more cooling elements, and a second portion including one or more cooling elements, the first portion at least partially implantable proximate one or more brown adipose tissues, the second portion at least partially implantable proximate a pulmonary vein; wherein inducing non-shivering thermogenesis in the brown adipose tissue includes activating the first portion implantable proximate the one or more brown adipose tissues so as to induce non-shivering thermogenesis of the brown adipose tissue, and activating at least the second portion implantable proximate the pulmonary vein so as to induce activation of thermoreceptors associated with the pulmonary vein, responsive to a detected target glucose level. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43)
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Specification