Methods and apparatus for tissue activation and monitoring

• US 8,700,148 B2
• Filed: 03/29/2007
• Issued: 04/15/2014
• Est. Priority Date: 09/02/2004
• Status: Active Grant

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark J.
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US11/731,236
• Publication Number:
  US 20070173897A1
• Time in Patent Office: 2,574 Days
• Field of Search: 600/300, 607/60, 607/9
• US Class Current: 607/9
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/341 Vectorcardiography [VCG]
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: A61N 1/37276 characterised by means for reducing power consumption during telemetry
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject'"'"'s body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

Claims

1. A medical apparatus for interacting with a body, the apparatus comprising:

a controller-power source with a first electrode adapted to contact the body;

a first satellite unit comprising satellite circuitry and a second electrode and adapted to be placed within the body, the satellite circuitry electrically connected to the second electrode and configured to control the second electrode based on data and power current from the controller-power source distally located from the satellite circuitry; and

a single conductor connected between the controller-power source and the first satellite unit, wherein the data and power current flow from the controller-power source through the single conductor, through the satellite circuitry, through the second electrode, through the body, through the first electrode, and to the controller-power source.

2. The apparatus of claim 1 wherein the satellite circuitry is data storage, address encoding, address decoding, logic, analog, mixed-signal, power recovery, clock recovery, data recovery, transmit, receive, electrode driver, sensor stimulation, or sensor detection circuitry.

3. The apparatus of claim 1 wherein the first electrode and the second electrode are connected to a detecting device inside the controller-power source.

4. The apparatus of claim 1 wherein the single conductor is formed as a wire.

5. The apparatus of claim 1 further comprising a plurality of satellite units electrically connected to the controller-power source via the single conductor, wherein the single conductor includes a mesh portion which connects the first satellite unit and the plurality of satellite units in a net-like arrangement.

6. The apparatus of claim 5 wherein the single conductor further includes a wire portion which connects the controller-power source and a node on the mesh portion.

7. The apparatus of claim 1 further comprising at least one additional satellite unit, wherein each of the at least one additional satellite unit comprises respective satellite circuitry distally located from the controller-power source.

8. The apparatus of claim 7 wherein the first satellite unit and the at least one additional satellite unit are arranged as a two-dimensional array.

9. The apparatus of claim 8 wherein the two-dimensional array is mounted on a flexible substrate.

10. The apparatus of claim 1 wherein the first satellite unit measures data selected from the group consisting of pressure data, volume data, dimension data, temperature data, oxygen or carbon dioxide concentration data, hematocrit data, electrical conductivity data, electrical potential data, pH data, chemical data, blood flow rate data, thermal conductivity data, optical property data, cross-sectional area data, viscosity data, and radiation data.

11. The apparatus of claim 1, wherein the first satellite unit further comprises at least one additional electrode, and wherein the satellite circuitry is configured to control activation of the second electrode and the at least one additional electrode based on the data and power current.

12. The apparatus of claim 1, wherein the first satellite unit further comprises a housing to contain the satellite circuitry and the second electrode.

13. The apparatus of claim 12, wherein the satellite circuitry is an integrated circuit embedded in the housing.