Devices and methods for treatment of heart failure and associated conditions

• US 8,700,162 B2
• Filed: 10/08/2012
• Issued: 04/15/2014
• Est. Priority Date: 06/16/2008
• Status: Active Grant

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Georgakopoulos, Dimitrios, Lovett, Eric Grant
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US13/646,824
• Publication Number:
  US 20130338735A1
• Time in Patent Office: 554 Days
• Field of Search: 607/2, 607/44
• US Class Current: 607/44
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: F01K 25/005 the working fluid being steam, created by combustion of hydrogen with oxygen
• CPC Class Codes: F02C 3/22 the fuel or oxidant being gaseous at standard temperature and pressure F02C3/28 takes precedence
• CPC Class Codes: F02C 3/30 Adding water, steam or other fluids for influencing combustion, e.g. to obtain cleaner exhaust gases F02C7/141, F02C7/30, F01D21/00, F01K21/04, F23D11/10 take precedence
• CPC Class Codes: F05D 2220/31 in steam turbines

Abstract

Devices and methods of use for identification, treatment and/or management of heart failure and/or associated conditions. An exemplary device may include a first sensor configured to monitor a parameter indicative of a fluid level in a pulmonary circulation of a patient, a second sensor configured to monitor a parameter indicative of a fluid level in a non-pulmonary circulation of a patient, and a control system coupled to the first sensor and second sensor. The control system is configured to provide a baroreflex therapy to the patient based at least in part on the parameter indicative of a fluid level in a pulmonary circulation and the parameter indicative of a fluid level in a non-pulmonary circulation. The baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.

Claims

1. A medical device comprising:

a first sensor configured to monitor a parameter indicative of a fluid level in a pulmonary circulation of a patient;

a second sensor configured to monitor a parameter indicative of a fluid level in a non-pulmonary circulation of a patient;

a control system coupled to the first sensor and second sensor, the control system configured to provide a baroreflex therapy to the patient based at least in part on the parameter indicative of a fluid level in a pulmonary circulation and the parameter indicative of a fluid level in a non-pulmonary circulation, wherein the baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.

2. The device of claim 1, wherein the second sensor is configured to monitor a splanchnic measurement representative of fluid status associated with a splanchnic organ.

3. The device of claim 1, wherein the control system is configured to provide the baroreflex therapy in response to at least one of a decrease in the parameter indicative of a fluid level in the non-pulmonary circulation below a specified threshold value or an increase in the parameter indicative of a fluid level in the pulmonary circulation above a specified threshold value.

4. A method, comprising:

monitoring an indicator of a fluid level in a pulmonary circulation of a patient;

monitoring an indicator of a fluid level in a non-pulmonary circulation of the patient;

delivering a baroreflex therapy based at least in part on the parameter indicative of a fluid level in a pulmonary circulation and the parameter indicative of a fluid level in a non-pulmonary circulation, wherein the baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.

5. The method of claim 4, wherein delivering the baroreflex therapy further comprises delivering the baroreflex therapy in response to a decrease in the indicator of a fluid level in the non-pulmonary circulation of the patient below a specified threshold value.

6. The method of claim 4, wherein delivering the baroreflex therapy further comprises decreasing or ceasing the baroreflex therapy in response to at least one of:

a change in the indicator of a fluid level in the pulmonary circulation beyond a predetermined threshold value;

or

a change in the indicator of a fluid level in the non-pulmonary circulation beyond a predetermined threshold value.

7. A method, comprising:

causing a baroreflex therapy system to be manufactured and made available to a user;

providing instructions recorded on a tangible medium to the user, the instructions comprising;

monitoring an indicator of a fluid level in a pulmonary circulation of the patient;

monitoring an indicator of a fluid level in a non-pulmonary circulation of the patient;

causing the baroreflex therapy system to deliver a baroreflex therapy based at least in part on the indicator of a fluid level in a pulmonary circulation and the indicator of a fluid level in a non-pulmonary circulation, wherein the baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.

8. The method of claim 7, wherein monitoring an indicator of a fluid level in a non-pulmonary circulation of the patient comprises monitoring a splanchnic measurement representative of fluid status associated with a splanchnic organ.

9. The method of claim 7, wherein causing the baroreflex therapy system to deliver a baroreflex therapy comprises delivering the baroreflex therapy in response to a decrease in the indicator of a fluid level in the non-pulmonary circulation of the patient below a specified threshold value.

10. The method of claim 7, wherein causing the baroreflex therapy system to deliver a baroreflex therapy comprises delivering the baroreflex therapy in response to an increase in the indicator of a fluid level in the pulmonary circulation of the patient above a specified threshold value.

11. The method of claim 7, wherein causing the baroreflex therapy system to deliver a baroreflex therapy comprises decreasing or ceasing the baroreflex therapy in response to at least one of:

a change in the indicator of a fluid level in the pulmonary circulation beyond a predetermined threshold value;

or

a change in the indicator of a fluid level in the non-pulmonary circulation beyond a predetermined threshold value.