Hemostatic devices and methods of making same

• US 8,709,463 B2
• Filed: 06/16/2006
• Issued: 04/29/2014
• Est. Priority Date: 06/25/2003
• Status: Expired due to Fees

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Looney, Dwayne Lee, Troger, Kenneth, Lamb, Bruce, Walthall, Benjamin
• Primary Examiner(s): Vu, Jake
• Application Number:
  US11/454,805
• Publication Number:
  US 20060233869A1
• Time in Patent Office: 2,874 Days
• Field of Search: 424/423
• US Class Current: 424/423
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 26/0023 Polysaccharides
• CPC Class Codes: A61L 26/0085 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 26/0095 Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: C08L 1/26 Cellulose ethers

Abstract

The present invention includes compositions suitable for use in a hemostatic device and hemostatic devices utilizing such compositions, as well as methods of making the compositions and the medical devices utilizing such compositions where the compositions contain biocompatible, oxidized cellulose particles having an average designated nominal particle size of about 0.035-4.35 mm and a biocompatible, water-soluble or water-swellable polysaccharide porous binder component.

Claims

1. A process for making a composition useful in a hemostatic device, comprising:

providing a polymer solution having a water-soluble or water-swellable polysaccharide polymer dissolved in a suitable solvent therefore wherein said polymer is sodium carboxymethyl cellulose,

providing biocompatible, oxidized cellulose particles that comprise carboxylic-oxidized regenerated cellulose and having an average designated nominal size from about of 0.035 to about 4.35 mm,

contacting said polymer solution with said oxidized cellulose particles under conditions effective to disperse said oxidized cellulose particles homogenously throughout said polymer solution to form a homogenous dispersion,

subjecting said polymer solution having said particles dispersed throughout to conditions effective to solidify said homogenous dispersion; and

removing said solvent from the solidified dispersion by lyophilization, thereby forming said composition in the form of a porous sponge having a thickness of between 2 mm and 10 mm comprising said particles and a porous, water-soluble or water-swellable polysaccharide polymer binder component.

2. The process of claim 1 wherein the weight ratio of said sodium carboxymethyl cellulose to said oxidized cellulose particles is from about 1:

99 to about 20;

80.

3. The process of claim 1 wherein the weight ratio of said sodium carboxymethyl cellulose to said oxidized cellulose particles is from about 3:

97 to about 10;

90.