Administration device having a bolus administration profile controller
First Claim
1. An administration device for subcutaneous administration of a liquid drug to tissue of a patient over an extended period of time, the administration device comprising:
- an administration unit, the administration unit comprising a drug reservoir and a pump unit;
a housing, the housing comprising the administration unit and being adapted to be carried by a patient over an extended period of time;
a cannula; and
a controller unit, the controller unit comprising a bolus administration profile controller, wherein;
the bolus administration profile controller receives a bolus volume of a bolus to be administered; and
determines based, at least in part, on the received bolus volume a bolus administration profile such that a depot volume of a depot is limited, said depot being a locally concentrated drug cloud in the subcutaneous tissue around the cannula, wherein the depot is a subcutaneous drug depot that is present during and shortly after the administration until the drug is absorbed by the tissue;
wherein the administration device is configured for the subcutaneous administration of the liquid drug; and
wherein the controller unit is configured to implement a code for the bolus administration based on an absorption model for the subcutaneous administration to determine a resulting depot volume of the bolus by accounting for a steady absorption bolus volume, a maximum steady absorption rate, and an administration time when the depot is empty at the beginning of the administration and when the depot is not empty, as a function of a time of zero at a beginning of administration to an administration time;
wherein the steady absorption bolus volume of the absorption model is given by;
B_steady=R_max·
T_adminwherein B_steady is the steady absorption bolus volume, R_max is the maximum steady absorption rate, and T_admin is the administration time;
wherein if the depot is empty at the beginning of the administration the resulting depot volume of the bolus while performing the administration is given as a function of time by;
2 Assignments
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Accused Products
Abstract
According to one embodiment, an administration device for subcutaneous administration of a liquid drug over an extended period of time is provided. The administration device may include an administration unit, a housing, and a controller unit. The administration unit may include a drug reservoir and a pump unit. The housing may include the administration unit and may be adapted to be carried by a patient over an extend period of time. The controller unit may include a bolus administration profile controller. The bolus administration profile controller receives a bolus volume of a bolus to be administered and determines based, at least in part, on the bolus volume a bolus administration profile such that a depot volume of a depot is limited.
8 Citations
22 Claims
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1. An administration device for subcutaneous administration of a liquid drug to tissue of a patient over an extended period of time, the administration device comprising:
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an administration unit, the administration unit comprising a drug reservoir and a pump unit; a housing, the housing comprising the administration unit and being adapted to be carried by a patient over an extended period of time; a cannula; and a controller unit, the controller unit comprising a bolus administration profile controller, wherein;
the bolus administration profile controller receives a bolus volume of a bolus to be administered; and
determines based, at least in part, on the received bolus volume a bolus administration profile such that a depot volume of a depot is limited, said depot being a locally concentrated drug cloud in the subcutaneous tissue around the cannula, wherein the depot is a subcutaneous drug depot that is present during and shortly after the administration until the drug is absorbed by the tissue;wherein the administration device is configured for the subcutaneous administration of the liquid drug; and wherein the controller unit is configured to implement a code for the bolus administration based on an absorption model for the subcutaneous administration to determine a resulting depot volume of the bolus by accounting for a steady absorption bolus volume, a maximum steady absorption rate, and an administration time when the depot is empty at the beginning of the administration and when the depot is not empty, as a function of a time of zero at a beginning of administration to an administration time; wherein the steady absorption bolus volume of the absorption model is given by;
B_steady=R_max·
T_adminwherein B_steady is the steady absorption bolus volume, R_max is the maximum steady absorption rate, and T_admin is the administration time; wherein if the depot is empty at the beginning of the administration the resulting depot volume of the bolus while performing the administration is given as a function of time by; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for controlling a pump unit of an administration device, the administration device being adapted for subcutaneous administration of a liquid drug to tissue of a patient over an extended period of time, the method comprising:
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providing a bolus volume of a bolus to be administered; providing a controller unit, the controller unit comprising a bolus administration profile controller and wherein the controller unit is configured to implement a code for the bolus administration based on an absorption model for the subcutaneous administration to determine a resulting depot volume of the bolus by accounting for a steady absorption bolus volume, a maximum steady absorption rate, and an administration time when a depot is empty at the beginning of the administration and when the depot is not empty, as a function of a time of zero at a beginning of administration to an administration time; wherein the steady absorption bolus volume of the absorption model is given by;
B_steady=R_max·
T_adminwherein B_steady is the steady absorption bolus volume, R_max is the maximum steady absorption rate, and T_admin is the administration time; wherein if the depot is empty at the beginning of the administration the resulting depot volume of the bolus while performing the administration is given as a function of time by; - View Dependent Claims (20, 21, 22)
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Specification