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Administration device having a bolus administration profile controller

  • US 8,715,268 B2
  • Filed: 08/18/2010
  • Issued: 05/06/2014
  • Est. Priority Date: 02/21/2008
  • Status: Active Grant
First Claim
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1. An administration device for subcutaneous administration of a liquid drug to tissue of a patient over an extended period of time, the administration device comprising:

  • an administration unit, the administration unit comprising a drug reservoir and a pump unit;

    a housing, the housing comprising the administration unit and being adapted to be carried by a patient over an extended period of time;

    a cannula; and

    a controller unit, the controller unit comprising a bolus administration profile controller, wherein;

    the bolus administration profile controller receives a bolus volume of a bolus to be administered; and

    determines based, at least in part, on the received bolus volume a bolus administration profile such that a depot volume of a depot is limited, said depot being a locally concentrated drug cloud in the subcutaneous tissue around the cannula, wherein the depot is a subcutaneous drug depot that is present during and shortly after the administration until the drug is absorbed by the tissue;

    wherein the administration device is configured for the subcutaneous administration of the liquid drug; and

    wherein the controller unit is configured to implement a code for the bolus administration based on an absorption model for the subcutaneous administration to determine a resulting depot volume of the bolus by accounting for a steady absorption bolus volume, a maximum steady absorption rate, and an administration time when the depot is empty at the beginning of the administration and when the depot is not empty, as a function of a time of zero at a beginning of administration to an administration time;

    wherein the steady absorption bolus volume of the absorption model is given by;


    B_steady=R_max·

    T_adminwherein B_steady is the steady absorption bolus volume, R_max is the maximum steady absorption rate, and T_admin is the administration time;

    wherein if the depot is empty at the beginning of the administration the resulting depot volume of the bolus while performing the administration is given as a function of time by;

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