Compositions and methods for improving cardiovascular health

• US 8,716,249 B2
• Filed: 01/31/2008
• Issued: 05/06/2014
• Est. Priority Date: 01/31/2008
• Status: Expired due to Fees

• Current Assignee: Energy Light, LLC
• Original Assignee: Energy Light, LLC
• Inventors: Wolfe, Robert, Troup, John, Deutz, Nicolaas (Mick) Emile Paulus
• Primary Examiner(s): Jiang, Shaojia Anna
• Assistant Examiner(s): Henry, Michael C
• Application Number:
  US12/023,413
• Publication Number:
  US 20090197820A1
• Time in Patent Office: 2,287 Days
• Field of Search: 514/23, 514/171, 536/1.11, 426/656
• US Class Current: 514/23
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Compositions and methods for improving cardiovascular health in the elderly by delivering a selection of essential amino acids, phytosterols, stanols, and isoflavones, which may be supplemented with a low glycemic carbohydrate and/or a medium chain fatty acid.

Claims

1. A composition of matter for improving cardiovascular health comprising:

an amino acid blend, the blend comprising;

about 0.36 g histidine;

about 0.94 g isoleucine;

about 3.95 g leucine;

about 1.88 g lysine;

about 0.39 g methionine;

about 0.51 g phenylalanine;

about 1.05 g threonine;

about 0.82 g valine; and

about 1.10 g arginine; and

at least one selected from the group consisting of;

citrulline;

a phytostenol,

a stanol, and

a isoflavone.

2. The composition of claim 1 further comprising a low glycemic carbohydrate.

3. The composition of claim 1 further comprising a medium chain fatty acid.

4. The composition of claim 1 wherein said phytostenol and said stanol are in a 2:

1 ratio.

5. The composition of claim 1 wherein said isoflavone has a combined mass of about 30 to about 40 g.

6. The composition of claim 2 wherein said low glycemic carbohydrate has a combined mass of about 0.01 to about 15 g.

7. The composition of claim 3 wherein said medium chain fatty acid has a combined mass of about 0.01 to about 15 g.

8. The composition of claim 1 further comprising supplemental minerals.

9. The composition of claim 1 further comprising vitamins.

10. The composition of claim 1 further comprising an excipient.

11. A composition of matter for the reduction of liver fat, the composition consisting essentially of:

about 0.36 g histidine;

about 0.94 g isoleucine;

about 3.95 g leucine;

about 1.88 g lysine;

about 0.39 g methionine;

about 0.51 g phenylalanine;

about 1.05 g threonine;

about 0.82 g valine; and

about 1.10 g arginine.