Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors

  • US 8,718,958 B2
  • Filed: 03/12/2012
  • Issued: 05/06/2014
  • Est. Priority Date: 10/26/2006
  • Status: Active Grant
First Claim
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1. A computer implemented method for detecting early signal attenuation in an analyte sensor, comprising:

  • receiving a first plurality of analyte sensor related signals within a first predetermined time period after insertion of an analyte sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion;

    determining a probability of early signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals;

    receiving a second plurality of analyte sensor related signals during a second predetermined time period, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time;

    receiving a reference analyte measurement during the second predetermined time period;

    determining a sensitivity of the analyte sensor based on the second plurality of analyte sensor related signals and the reference analyte measurement;

    determining a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the analyte sensor is manufactured;

    verifying a presence of early signal attenuation when the determined sensitivity ratio is less than a first predetermined threshold level; and

    generating a first output signal with a processor associated with the verification of the presence of early signal attenuation.

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